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. 1974 Sep;6(3):274–281. doi: 10.1128/aac.6.3.274

Treatment of Pneumonia and Other Serious Bacterial Infections with Cephapirin

Hugh G Robson 1, M Ian Bowmer 1
PMCID: PMC444637  PMID: 15830473

Abstract

Nineteen patients with pneumonia due to Streptococcus pneumoniae, Staphylococcus aureus, Klebsiella pneumoniae, or Escherichia coli were treated with 4 to 18 g of cephapirin daily. There were three treatment failures. One patient each with pneumonia due to E. coli or S. pneumoniae died despite apparent eradication of the pathogen. Lobar pneumonia due to K. pneumoniae progressed during therapy in a third patient to lung gangrene, necessitating pneumonectomy. Five additional patients with pneumococcal pericarditis or septic bursitis, empyema, cannula-associated bacteremia, and thoractomy wound infection due to S. aureus were cured. All isolates of S. aureus, S. pneumoniae, and group A Streptococcus were inhibited by 0.8 μg of cephapirin per ml; minimal inhibitory concentrations of cephalothin were similar. Ninety percent of K. pneumoniae, 85% of Proteus mirabilis, 73% of E. coli, and 30% of Enterobacter were inhibited by 12.5 μg cephapirin per ml. All isolates of Pseudomonas, Serratia and indole-positive Proteus had a cephapirin minimal inhibitory concentration of [Formula: see text] 100 μg/mg. Serum concentrations after intravenous and intramuscular injection were similar to those reported for cephalothin. The intramuscular injections were moderately painful, and intravenous infusions caused phlebitis in three of nine patients treated with doses up to 18 g per day. Cephapirin appears comparable to cephalothin in vitro and is an effective agent in treatment of infection due to S. aureus and S. pneumoniae.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Axelrod J., Meyers B. R., Hirschman S. Z. Cephapirin: in vitro antibacterial spectrum. Appl Microbiol. 1971 Nov;22(5):904–908. doi: 10.1128/am.22.5.904-908.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Bodner S. J., Koenig M. G. Clinical and in vitro evaluation of cephapirin: a new parenteral cephalosporin. Am J Med Sci. 1972 Jan;263(1):43–51. doi: 10.1097/00000441-197201000-00007. [DOI] [PubMed] [Google Scholar]
  3. Bran J. L., Levison M. E., Kaye D. Clinical and in vitro evaluation of cephapirin, a new cephalosporin antibiotic. Antimicrob Agents Chemother. 1972 Jan;1(1):35–40. doi: 10.1128/aac.1.1.35. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Carrizosa J., Levison M. E., Kaye D. Double-blind controlled comparison of phlebitis produced by cephapirin and cephalothin. Antimicrob Agents Chemother. 1973 Feb;3(2):306–307. doi: 10.1128/aac.3.2.306. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Gordon R. C., Barrett F. F., Clark D. J., Yow M. D. Laboratory and pharmacologic studies of BL-P-1322 (cephapirin sodium) in children. Curr Ther Res Clin Exp. 1971 Jun;13(6):398–406. [PubMed] [Google Scholar]
  6. Inagaki J., Bodey G. P. Phlebitis associated with cephalosporins: cephapirin versus cephalothin. Curr Ther Res Clin Exp. 1973 Feb;15(2):37–43. [PubMed] [Google Scholar]
  7. Lane A. Z., Taggart J. G., Iles R. L. Relative incidence of phlebitis caused by continuous intravenous infusion of cephapirin and cephalothin. Antimicrob Agents Chemother. 1972 Sep;2(3):234–235. doi: 10.1128/aac.2.3.234. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Levison M. E., Bran J. L., Jepson J. H., Kaye D. Neutropenia associated with cephapirin therapy. Antimicrob Agents Chemother. 1972 Feb;1(2):174–176. doi: 10.1128/aac.1.2.174. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Linton A. L., Bailey R. R., Turnbull D. I. Relative nephrotoxicity of cephalosporin antibiotics in an animal model. Can Med Assoc J. 1972 Sep 9;107(5):414–416. [PMC free article] [PubMed] [Google Scholar]
  10. McCloskey R. V., Terry E. E., McCracken A. W., Sweeney M. J., Forland M. F. Effect of hemodialysis and renal failure on serum and urine concentrations of cephapirin sodium. Antimicrob Agents Chemother. 1972 Feb;1(2):90–93. doi: 10.1128/aac.1.2.90. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Sanders W. E., Jr, Johnson J. E., 3rd, Taggart J. G. Adverse reactions to cephalothin and cephapirin. Uniform occurrence on prolonged intravenous administration of high doses. N Engl J Med. 1974 Feb 21;290(8):424–429. doi: 10.1056/NEJM197402212900803. [DOI] [PubMed] [Google Scholar]
  12. Wiesner P., MacGregor R., Bear D., Berman S., Holmes K., Turck M. Evaluation of a new cephalosporin antibiotic, cephapirin. Antimicrob Agents Chemother. 1972 Apr;1(4):303–309. doi: 10.1128/aac.1.4.303. [DOI] [PMC free article] [PubMed] [Google Scholar]

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