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. 1974 Sep;6(3):324–326. doi: 10.1128/aac.6.3.324

5-Fluorocytosine and Amphotericin B in Bronchial Secretions

James E Pennington 1, Edward R Block 1, Herbert Y Reynolds 1
PMCID: PMC444645  PMID: 15830481

Abstract

The penetration into and clearance from bronchial secretions of 5-fluorocytosine and amphotericin B were studied in a dog model. After a single intravenous dose of 35 mg/kg, 5-fluorocytosine intrabronchial concentrations were greater than the minimal inhibitory concentration for 80 to 90% of Candida species. These inhibitory concentrations persisted up to 3 h. In contrast, amphotericin B in intravenous doses of 0.6 and 1.2 mg/kg penetrated the blood-bronchus barrier poorly.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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