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Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1974 Sep;6(3):360–365. doi: 10.1128/aac.6.3.360

Inhibition of Herpes Simplex Virus Replication by Phosphonoacetic Acid

L R Overby 1, E E Robishaw 1, J B Schleicher 1, A Rueter 1, N L Shipkowitz 1, J C-H Mao 1
PMCID: PMC444651  PMID: 15830487

Abstract

Replication of herpes simplex virus in WI-38 cells was inhibited by phosphonoacetic acid, as measured by decreased virus cytopathogenic effect and incorporation of radiolabeled thymidine in virus-infected cells. The drug appeared to have no effect on adsorption, penetration, or release of the virus nor on the synthesis of ribonucleic acid or protein. It appeared to inhibit virus deoxyribonucleic acid synthesis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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