Abstract
Patients with urinary tract infection were treated for 8 to 15 days with one daily intramuscular injection of 160 mg of gentamicin or 60 or 80 mg every 8 h. Ten of 11 patients treated with one injection daily were cured as compared with 8 of 10 patients treated with three injections daily. Urinary concentrations of gentamicin were 3.2 to 600 μg/ml in all 8-h collections in patients receiving one injection daily and were 22 to 440 μg/ml in all 8-h collections in patients receiving three injections daily. The group treated once daily demonstrated a significant but reversible increase in mean serum creatinine concentration and decrease in mean creatinine clearance during therapy as compared with no change in the group treated with three injections daily. Decreases in renal function were correlated with higher milligram per kilogram doses and higher 1-h serum concentrations.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bauer A. W., Kirby W. M., Sherris J. C., Turck M. Antibiotic susceptibility testing by a standardized single disk method. Am J Clin Pathol. 1966 Apr;45(4):493–496. [PubMed] [Google Scholar]
- Cox C. E. Gentamicin, a new aminoglycoside antibiotic: clinical and laboratory studies in urinary tract infection. J Infect Dis. 1969 Apr-May;119(4):486–491. doi: 10.1093/infdis/119.4-5.486. [DOI] [PubMed] [Google Scholar]
- Jackson G. G., Riff L. J. Pseudomonas bacteremia: pharmacologic and other bases for failure of treatment with gentamicin. J Infect Dis. 1971 Dec;124 (Suppl):S185–S191. doi: 10.1093/infdis/124.supplement_1.s185. [DOI] [PubMed] [Google Scholar]
- Levison M. E., Knight R., Kaye D. In vitro evaluation of tobramycin, a new aminoglycoside antibiotic. Antimicrob Agents Chemother. 1972 May;1(5):381–384. doi: 10.1128/aac.1.5.381. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Levison M. E., Levison S. P., Ries K., Kaye D. Pharmacology of cefazolin in patients with normal and abnormal renal function. J Infect Dis. 1973 Oct;128(Suppl):S354–S357. doi: 10.1093/infdis/128.supplement_2.s354. [DOI] [PubMed] [Google Scholar]
- Ries K., Levison M. E., Kaye D. In vitro evaluation of a new aminoglycoside derivative of kanamycin, a comparison with tobramycin and gentamycin. Antimicrob Agents Chemother. 1973 Apr;3(4):532–533. doi: 10.1128/aac.3.4.532. [DOI] [PMC free article] [PubMed] [Google Scholar]
- STAMEY T. A., GOVAN D. E., PALMER J. M. THE LOCALIZATION AND TREATMENT OF URINARY TRACT INFECTIONS: THE ROLE OF BACTERICIDAL URINE LEVELS AS OPPOSED TO SERUM LEVELS. Medicine (Baltimore) 1965 Jan;44:1–36. doi: 10.1097/00005792-196501000-00001. [DOI] [PubMed] [Google Scholar]
- Steigbigel N. H., McCall C. E., Reed C. W., Finland M. Antibacterial action of "broad-spectrum" penicillins, cephalosporins and other antibiotics against Gram-negative bacilli isolated from bacteremic patients. Ann N Y Acad Sci. 1967 Sep 27;145(2):224–236. doi: 10.1111/j.1749-6632.1967.tb50221.x. [DOI] [PubMed] [Google Scholar]
- Wilfert J. N., Burke J. P., Bloomer H. A., Smith C. B. Renal insufficiency associated with gentamicin therapy. J Infect Dis. 1971 Dec;124 (Suppl):S148–S155. doi: 10.1093/infdis/124.supplement_1.s148. [DOI] [PubMed] [Google Scholar]