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. 1974 Oct;6(4):507–511. doi: 10.1128/aac.6.4.507

Post-Exposure Prophylaxis of Murine Rabies with Polyinosinic-Polycytidylic Acid and Chlorite-Oxidized Amylose1

Maurice W Harmon 1,2, Burton Janis 1,2, Hilton B Levy 1,2
PMCID: PMC444680  PMID: 4157354

Abstract

Chlorite-oxidized amylose (COAM), polyinosinic-polycytidylic acid [poly(I:C)], and combinations of the two drugs were evaluated for their interferon-inducing properties and their ability to protect mice against rabies infection. Post-exposure administration of one or two doses (100 μg each) of poly(I:C) significantly protected mice against rabies infection. Pretreatment of mice with COAM 3 h before poly(I:C) stimulation resulted in an enhancement of the interferon response. However, the increased interferon titers were not reflected by increased protection against rabies infection over that achieved with poly(I:C) therapy alone. Therapy with COAM alone did not protect mice against rabies but, rather, was associated with enhanced mortality.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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