Abstract
The absorption and excretion of equivalent doses of ampicillin, pivampicillin, and amoxycillin were compared in 10 healthy volunteers after administration of these antibiotics in a randomized triple crossover fashion. As recommended, ampicillin and amoxycillin were administered on an empty stomach, whereas pivampicillin was given with breakfast. The mean half-life times were nearly identical for all three antibiotics: 60.9 min for ampicillin; 58.4 min for pivampicillin; and 62.2 min for amoxycillin. The absorption of the drugs was evaluated according to the following three criteria: the mean peak serum levels; the “area under the curve”; and the percentage of recovery in urine. By these criteria, pivampicillin was the best-absorbed drug, with absorption 3.0 to 3.6 times higher than that of ampicillin and 1.2 to 1.5 times higher than that of amoxycillin, whereas the absorption of amoxycillin was 2.1 to 2.9 times higher than that of ampicillin.
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Selected References
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- Bodey G. P., Nance J. Amoxicillin: in vitro and pharmacological studies. Antimicrob Agents Chemother. 1972 Apr;1(4):358–362. doi: 10.1128/aac.1.4.358. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Daehne W., Frederiksen E., Gundersen E., Lund F., Morch P., Petersen H. J., Roholt K., Tybring L., Godtfredsen W. O. Acyloxymethyl esters of ampicillin. J Med Chem. 1970 Jul;13(4):607–612. doi: 10.1021/jm00298a005. [DOI] [PubMed] [Google Scholar]
- Frederiksen E., Godtfredsen W. O., Nielsen B., Roholt K. Pivampicillinkloid--et nyt bredspektret antibiotikum til oral anvendelse. Nord Med. 1971 Nov 25;86(47):1376–1380. [PubMed] [Google Scholar]
- Gordon C., Regamey C., Kirby W. M. Comparative clinical pharmacology of amoxicillin and ampicillin administered orally. Antimicrob Agents Chemother. 1972 Jun;1(6):504–507. doi: 10.1128/aac.1.6.504. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hultberg E. R., Backelin B. Studies on the absorption of pivampicillin and ampicillin. Scand J Infect Dis. 1972;4(2):149–153. doi: 10.3109/inf.1972.4.issue-2.16. [DOI] [PubMed] [Google Scholar]