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. 1974 Nov;6(5):594–597. doi: 10.1128/aac.6.5.594

Antivirion Effects of Streptovaricin Complex Against Friend Virus

Julius S Horoszewicz 1,2, Susan S Leong 1,2, Daniel M Byrd 1,2, William A Carter 1,2
PMCID: PMC444698  PMID: 15825311

Abstract

The in vitro antivirion activities of five different streptovaricin complex lots against the polycythemic strain of the Friend virus were evaluated. The assay system was based on the inhibition of the Friend virus-induced spleen foci. The virus inactivation process was shown to be susceptible to variation in temperature, pH, and time. The antivirion activity and the acute toxicity for mice, as well as the optical properties of these streptovaricin complexes, do not co-vary; this suggests that their biological activities are not associated with a single molecular structure. In addition, the antivirion activity of the five preparations of streptovaricin complex differs about 30-fold, indicating that this activity does not reside in a major component of the complex.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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