Skip to main content
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1974 Nov;6(5):620–624. doi: 10.1128/aac.6.5.620

Antimicrobial Susceptibility of Haemophilus influenzae

Clyde Thornsberry 1, Linda A Kirven 1
PMCID: PMC444703  PMID: 15825316

Abstract

Selected clinical isolates of Haemophilus influenzae were tested for their susceptibility to seven antibiotics by a microtiter broth dilution and an agar diffusion method. Eleven of 40 strains tested were resistant to ampicillin, the drug of choice, by both methods. All the strains tested were susceptible to chloramphenicol, and all but one were susceptible to tetracycline. Of the other four antibiotics tested, the ranges of minimal inhibitory concentrations (MICs) were: 0.5 to 4 μg of gentamicin per ml, 0.5 to 4 μg of erythromycin per ml, and 2 to 16 μg of clindamycin per ml. MICs of ampicillin for both the susceptible and resistant strains were markedly affected by inoculum concentration. The ampicillin MICs of the resistant strains were also affected by the time of incubation.

Full text

PDF
620

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barrett F. F., Taber L. H., Morris C. R., Stephenson W. B., Clark D. J., Yow M. D. A 12 year review of the antibiotic management of Hemophilus influenzae meningitis. Comparison of ampicillin and conventional therapy including chloramphenicol. J Pediatr. 1972 Aug;81(2):370–377. doi: 10.1016/s0022-3476(72)80316-0. [DOI] [PubMed] [Google Scholar]
  2. HIRSCH H. A., FINLAND M. Susceptibility of Hemophilus influenzae to 21 antibiotics in vitro. Am J Med Sci. 1960 Jan;239:33–40. doi: 10.1097/00000441-196001000-00005. [DOI] [PubMed] [Google Scholar]
  3. Haltalin K. C., Smith J. B. Reevaluation of ampicillin therapy for Hemophilus influenzae meningitis. An appraisal based on a review of cases of persistent or recurrent infection. Am J Dis Child. 1971 Oct;122(4):328–336. [PubMed] [Google Scholar]
  4. McLinn S. E., Nelson J. D., Haltalin K. C. Antimicrobial susceptibility of Hemophilus influenzae. Pediatrics. 1970 May;45(5):827–838. [PubMed] [Google Scholar]
  5. Nelson K. E., Levin S., Spies H. W., Lepper M. H. Treatment of Hemophilus influenzae meningitis: a comparison of chloramphenicol and tetracycline. J Infect Dis. 1972 May;125(5):459–465. doi: 10.1093/infdis/125.5.459. [DOI] [PubMed] [Google Scholar]
  6. Newman R. B. Identification of Haemophilus influenzae. CRC Crit Rev Clin Lab Sci. 1972 Jan;3(1):103–129. doi: 10.3109/10408367209151323. [DOI] [PubMed] [Google Scholar]
  7. Schulkind M. L., Altemeier W. A., 3rd, Ayoub E. M. A comparison of ampicillin and chloramphenicol therapy in Hemophilus influenzae meningitis. Pediatrics. 1971 Sep;48(3):411–416. [PubMed] [Google Scholar]
  8. THRUPP L. D., LEEDOM J. M., IVLER D., WEHRLE P. F., BROWN J. F., MATHIES A. W., PORTNOY B. H. INFLUENZAE MENINGITIS: A CONTROLLED STUDY OF TREATMENT WITH AMPICILLIN. Postgrad Med J. 1964 Dec;40:SUPPL–SUPPL:126. doi: 10.1136/pgmj.40.suppl.119. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Wehrle P. F., Mathies A. W., Jr, Leedom J. M. The critically ill child: management of acute bacterial meningitis. Pediatrics. 1969 Dec;44(6):991–998. [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES