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. 1994 Aug 2;91(16):7717–7721. doi: 10.1073/pnas.91.16.7717

Structure and expression of the hairless gene of mice.

M B Cachon-Gonzalez 1, S Fenner 1, J M Coffin 1, C Moran 1, S Best 1, J P Stoye 1
PMCID: PMC44473  PMID: 8052649

Abstract

The hairless mutation of mice was caused by insertion of a murine leukemia virus. Starting with sequences flanking the provirus, a series of overlapping clones surrounding the viral integration site were obtained. By using a combination of sequencing, PCR, and exon-trapping techniques, the hairless gene was identified. It encodes a predicted protein of 1182 amino acids, including a potential zinc-finger domain. The expression patterns of the gene closely reflect the phenotype of animals carrying the hairless mutation.

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Selected References

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