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. 1974 Dec;6(6):783–784. doi: 10.1128/aac.6.6.783

In Vitro Inhibition of Coccidioides Immitis Strains with Amphotericin B Plus Rifampin

David Rifkind 1, Ellen D Crowder 1, Robert N Hyland 1
PMCID: PMC444736  PMID: 4451350

Abstract

Rifampin was shown in vitro to decrease the amphotericin B minimal inhibitory concentrations of all of 10 strains of Coccidioides immitis tested. These decreases ranged from two- to fourfold and occurred with rifampin concentrations of 10 to 40 μg/ml. Rifampin alone was without effect.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Atkinson A. J., Jr, Bindschadler D. D. Pharmacokinetics of intrathecally administered amphotericin B. Am Rev Respir Dis. 1969 Jun;99(6):917–924. doi: 10.1164/arrd.1969.99.6.917. [DOI] [PubMed] [Google Scholar]
  2. Devine L. F., Johnson D. P., Hagerman C. R., Pierce W. E., Rhode S. L., 3rd, Peckinpaugh R. O. Rifampin. Levels in serum and saliva and effect on the meningococcal carrier state. JAMA. 1970 Nov 9;214(6):1055–1059. doi: 10.1001/jama.214.6.1055. [DOI] [PubMed] [Google Scholar]
  3. Grassi G. G., Pozzi E. Effect of rifampicin on delayed-hypersensitivity reactions. J Infect Dis. 1972 Nov;126(5):542–544. doi: 10.1093/infdis/126.5.542. [DOI] [PubMed] [Google Scholar]
  4. HYDE L. Coccidioidal pulmonary cavitation. Am J Med. 1958 Dec;25(6):890–897. doi: 10.1016/0002-9343(58)90061-5. [DOI] [PubMed] [Google Scholar]
  5. Kobbayashi G. S., Medoff G., Schlessinger D., Kwan C. N., Musser W. E. Amphotericin B potentiation of rifampicin as an antifungal agent against the yeast phase of Histoplasma capsulatum. Science. 1972 Aug 25;177(4050):709–710. doi: 10.1126/science.177.4050.709. [DOI] [PubMed] [Google Scholar]
  6. Medoff G., Kobayashi G. S., Kwan C. N., Schlessinger D., Venkov P. Potentiation of rifampicin and 5-fluorocytosine as antifungal antibiotics by amphotericin B (yeast-membrane permeability-ribosomal RNA-eukaryotic cell-synergism). Proc Natl Acad Sci U S A. 1972 Jan;69(1):196–199. doi: 10.1073/pnas.69.1.196. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Ostrow J. H. Levels of rifampin in cerebrospinal fluid. Chest. 1973 Apr;63(4):648–649. doi: 10.1378/chest.63.4.648. [DOI] [PubMed] [Google Scholar]
  8. SANFORD W. G., RASCH J. R., STONEHILL R. B. A therapeutic dilemma. The treatment of disseminated coccidioidomycosis with amphotericin B. Ann Intern Med. 1962 Apr;56:553–563. doi: 10.7326/0003-4819-56-4-553. [DOI] [PubMed] [Google Scholar]
  9. Vall-Spinosa A., Lester W., Moulding T., Davidson P. T., McClatchy J. K. Rifampin in the treatment of drug-resistant mycobacterium tuberculosis infections. N Engl J Med. 1970 Sep 17;283(12):616–621. doi: 10.1056/NEJM197009172831202. [DOI] [PubMed] [Google Scholar]
  10. Verbist L., Gyselen A. Antituberculous activity of rifampin in vitro and in vivo and the concentrations attained in human blood. Am Rev Respir Dis. 1968 Dec;98(6):923–932. doi: 10.1164/arrd.1968.98.6.923. [DOI] [PubMed] [Google Scholar]
  11. WINN W. A. Coccidioidomycosis. The need for careful evaluation of the clinical pattern and anatomical lesions. Arch Intern Med. 1960 Oct;106:463–466. doi: 10.1001/archinte.1960.03820040001001. [DOI] [PubMed] [Google Scholar]

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