Correction
Following publication of this article [1], we recently noticed that two subjects in this study were not assigned to the correct genetic groups. One of the AA homozygotes was incorrectly entered as a C allele carrier and we had the opposite situation for a second subject.
We have re-run the primary statistical analysis with the subjects assigned to their correct groups. The corrected analysis produced very similar results to our initial, published findings as we observed a significant treatment effect and a significant genotype x treatment interaction due to a higher degree of response in the AA homozygotes.
Correcting our dataset did result in very slight differences in the mean values for 40 k time. The changes are presented in Table 1.
Table 1.
.
| Genotype | Placebo | Caffeine |
| A. Original Data: 40-km cycling time for Placebo and Caffeine conditions for AA homozygotes and C-allele carriers | ||
| AA | 76.1 +/- 5.8 min | 72.4 +/- 4.2 min |
| C | 72.2 +/- 4.2 min | 70.4 +/- 4.3 min |
| B. Corrected Data: 40-km cycling time for Placebo and Caffeine conditions for AA homozygotes and C-allele carriers | ||
| AA | 75.1 +/- 6.1 min | 71.6 +/- 4.3 min |
| C | 73.1 +/- 4.5 min | 71.6 +/- 4.4 min |
Footnotes
The online version of the original article can be found under doi:10.1186/1550-2783-9-7.
Contributor Information
Christopher J Womack, Email: womackcx@jmu.edu.
Michael J Saunders, Email: womackcx@jmu.edu.
Marta K Bechtel, Email: womackcx@jmu.edu.
David J Bolton, Email: womackcx@jmu.edu.
Michael Martin, Email: womackcx@jmu.edu.
Nicholas D Luden, Email: womackcx@jmu.edu.
Wade Dunham, Email: womackcx@jmu.edu.
Melyssa Hancock, Email: womackcx@jmu.edu.
References
- 1.Womack D, et al. The influence of a CYP1A2 polymorphism on the ergogenic effects of caffeine. J Int Soc Sports Nutri. 2012;9:7. doi: 10.1186/1550-2783-9-7. [DOI] [PMC free article] [PubMed] [Google Scholar]