TABLE 1 .
Disease and function analysis of 2-fold significantly changed genes by RNA-Seq
| Category | Disease and function | P value | Activation z score and predicted activation | Genes |
|---|---|---|---|---|
| Cancer | Cancer | 5.16E−12 | −0.231 | ABLIM1, ACTA2, ACTL8, ADAMTS1, ADAMTS3, ADAMTSL3, ADM, ALCAM, ALDH1A1, ANGPT1, ANPEP, ANXA1, APOBEC3B, ARAP2, AREG, ARHGAP18, ASXL3, ATP2B4, B3GAT1, BAMBI, BICC1, BIRC3, C11orf63, C1QTNF9B-AS1, CADM1, CAV1, CD36, CDC20B, CDCA7L, CDH19, CHRDL1, CILP2, CNTFR, COL3A1, COL9A2, COTL1, CPA6, CPED1, CRAT, CRIP1, CSAG4, CXorf57, CYLD, DACH2, DCP1B, DDX58, DDX60L, DGAT2, DIRAS3, DKK1, DLX6, DMD, DNM3, DPPA2, DSEL, DSG2, EFHD2, EGFR, EGLN3, EMB, EMP2, ENPP2, EPHA5, EPHA8, EPHB1, EPHX2, ERAP2, FANK1, FAT3, FBXL7, FBXO8, FERMT1, FES, FGF12, FXYD5, FZD1, GAGE1, GAGE13, GALNT14, GAP43, GAS1, GBE1, GCNT4, GLI1, GLRX2, GMPR, GNAL, GNAO1, GNMT, GPM6A, GPR37, GPRC5A, GRB10, GREM1, GRPR, HHIP, HMX2, HORMAD1, HOXA5, HOXB6, HPGD, HRASLS, HSPB6, IFIH1, INPP1, IQCA1, ITGAV, ITGB8, JAG1, JAM2, KCNJ8, KCNK1, KIRREL, KITLG, KLHDC8A, LAMA1, LGALS3, LGI2, LPCAT2, LRRC4B, LRRCC1, MACC1, MAGEA1, MAGEA12, MAP2, MDFI, MET, MFAP5, MLKL, MMP10, MMP14, MMP3, MYOF, NAV1, NCAM2, NFKB2, NFKBIA, NID1, NMBR, NPFFR2, NPTX1, NPW, NRCAM, NRIP1, NTRK3, OLFM1, OSR1, OTOL1, PAPLN, PAPSS2, PARP8, PCDHB5, PDE1A, PDGFRA, PDPN, PI15, PKD1L1, PLK2, PLXDC2, PMAIP1, PREX2, PROK2, PRRG1, PRRX1, PSMB9, PTGS2, PTPRD, PVRL3, RALYL, RARB, RBP1, RDH10, RELB, RGS2, RGS5, RNF128, RNF217, ROR1, RORB, S100A10, S100A2, SCG2, SDPR, SERPINE2, SERPING1, SERTAD4, SGCG, SGK1, SHH, SKAP1, SLAIN1, SLC1A6, SLC38A4, SLC7A7, SLC9A2, SLIT2, SLITRK1, SLITRK6, SNX7, SORL1, SPRY4, SSPN, STK32B, SULF2, TEK, TENM1, TEX14, TFPI, TFPI2, THRB, TIMP3, TMC1, TMC4, TMX4, TNFRSF19, TNFSF10, TOM1L2, TP53AIP1, TRIB2, TSNAXIP1, TTBK1, TWISTNB, USP44, VASH2, VGLL3, VSTM2L, VSTM4, WLS, ZFP28, ZFPM2, ZNF160, ZNF222, ZNF28, ZNF329, ZNF462, ZNF468, ZNF471, ZNF600, ZNF606, ZNF611, ZNF667, ZNF781, ZNF788, ZNF804A, ZSCAN18 |
| Cellular development, cellular growth and proliferation | Proliferation of tumor cell lines | 4.00E−04 | 2.472 Increase | ADAMTS1, ADM, ALCAM, ALDH1A1, ANXA1, AREG, B3GAT1, C1QTNF9B-AS1, CAV1, DDX58, DIRAS3, DKK1, EGFR, FES, GAP43, GLI1, GNMT, HMX2, HPGD, HSPB6, ITGAV, ITGB8, JAG1, KITLG, LGALS3, MET, MMP14, NFKBIA, NRIP1, NTRK3, PDGFRA, PTGS2, RARB, RELB, ROR1, S100A10, SGK1, SHH, TEK, TFPI2, THRB, TIMP3, TNFSF10, TP53AIP1, TRIB2, VASH2 |
| Cellular movement | Invasion of epithelial cell lines | 1.62E−04 | 2.213 Increase | AREG, EGFR, GLI1, NFKBIA, PTGS2 |
| Cell signaling | Cell surface receptor-linked signal transduction | 3.59E−04 | 2.207 Increase | ADAMTS1, ANGPT1, CAV1, COL3A1, GAS1, GLI1, HHIP, ITGAV, PRRX1, PTPRD, SERPINE2, SHH, TEK |
| Cell death and survival | Apoptosis of tumor cell lines | 4.56E−05 | −2.575 Decrease | ADM, ALCAM, ANKRD1, AREG, BIRC3, CAV1, CYLD, DDX58, DIRAS3, DKK1, DSG2, EGFR, GAS1, GLI1, GRB10, HOXA5, ITGAV, JAG1, KITLG, LGALS3, MET, MMP14, NFKB2, NFKBIA, NFKBIZ, NTRK3, PLK2, PMAIP1, PTGS2, RARB, RELB, ROR1, SEMA3A, SGK1, SH3RF1, SHH, SULF2, TIMP3, TNFRSF6B, TNFSF10, TP53AIP1, VASH2 |
| Cell morphology, cellular assembly and organization | Formation of cellular protrusions | 3.01E−07 | −2.212 Decrease | ANPEP, AREG, CAV1, CRIP1, DNM3, EGFR, EPHA8, EPHB1, FES, GAP43, GNAO1, GPM6A, ITGB8, KITLG, LAMA1, LRRC16A, MAP2, MET, NFKBIA, NRCAM, NTRK3, PDGFRA, PDPN, PREX2, PVRL3, RELB, ROR1, SEMA3A, SGK1, SHH, SLIT2, SLITRK1, SLITRK6, SULF2, TEX14, TNFRSF6B |