Skip to main content
. Author manuscript; available in PMC: 2015 Jun 3.
Published in final edited form as: Chemistry. 2013 Nov 18;19(52):17891–17898. doi: 10.1002/chem.201303239

Figure 1.

Figure 1

Structural representations of (1) native FITC-MSNs; (2) primary amine modified MSNs (a, b and c having 1, 5 and 10 mol% amination respectively); (3) 1 mol% imidazole modified MSNs; (4) 1 mol% primary amine and imidazole co-modified MSNs; (5) 1 mol % imidazole and carboxyl co-modified MSNs. Functional group pKa values and a summary of hydrodynamic diameter (dhyd), polydispersity index (PDI), ζ potential at two relevant pH boundaries, charging capacity and cytosol accessibility are also included. Data indicates surface modifications only have minor effects on particle hydrodynamic size and distribution (PDI values <0.3 across all particle types indicate excellent particle size distribution and colloidal stability). A typical TEM image of MSNs (95±8) nm is also shown in the first row (scale bar 100 nm). Note that DLS measures sizes based on the solvation state of particles in solution, resulting in larger values than that obtained from TEM.