. sPLA2-IIA enzymatic inhibition by S3319 partially reverses H2O2 induced oligodendrocyte cell death. Pretreatment with 1.25 μM S3319, a sPLA2 inhibitor, decreases cytotoxicity of a 30 min, 10 mM H2O2 pulse by by 17.9 %. (n = 7 wells per group, all in vitro studies repeated in triplicate, mean ± SD; * p<0.05, ** p < 0.01, *** p < 0.001).