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. Author manuscript; available in PMC: 2015 Jun 13.
Published in final edited form as: J Am Psychiatr Nurses Assoc. 2011 Jun 10;17(4):283–296. doi: 10.1177/1078390311408900

Pre-migration persecution, post-migration stressors and resources, and post-migration mental health: A study of severely traumatized U.S. Arab immigrant women

Anne E Norris 1,*, Karen J Aroian 2, David Nickerson 3
PMCID: PMC4464810  NIHMSID: NIHMS696358  PMID: 21835819

Abstract

Background

Competing theories exist regarding the importance of pre-migration trauma as compared to post-migration stressors and resources with respect to the risk to immigrant mental health.

Objective

To examine how type of pre-migration trauma, post-migration stressors, and post-migration resources differentially predict PTSD and MDD symptomatology in Arab immigrant women who have been exposed to pre-migration trauma.

Design

Descriptive; using multinomial logistic regression to explain membership in one of four groups: (a) PTSD only (n = 14); (b) major depressive disorder (MDD) (n = 162), (c) Co-Morbid PTSD-MDD (n = 148), (d) Subclinical Symptoms (n = 209).

Results

Post-immigration related stressors (as measured by the Demands of Immigration (DI)) had the strongest effect: Parameter estimates indicated that a unit increase in DI scores was associated with a nearly 17 fold increase in the likelihood of being in the Co-morbid relative to the Subclinical group, and a nearly 2.5 increase in the likelihood of being in the Co-Morbid relative to the MDD only group (p < .05). Social support, age and type of pre-migration trauma had smaller effects and only differentiated between Subclinical and Co-Morbid PTSD-MDD groups (p < .05).

Conclusion

Post-migration stressors exert substantive effects on immigrant mental health outcomes. Nursing interventions are needed to reduce immigration related stressors. Screening Arab immigrant women for depression and PTSD is important given high levels observed in this community based sample.


Immigrants who experience trauma in their country of origin prior to immigration are at risk for post-traumatic stress disorder (PTSD) and major depressive disorder (MDD; e.g., Robjant, Robbins, & Senior, 2009). However, competing theories exist regarding the importance of pre-migration trauma as compared to the post-migration period with respect to the causes of these illnesses. Beiser (1999, 2006) has theorized that post-migration stress and social resources have a greater impact on the risk for mental illnesses than pre-migration experiences, arguing that what occurs during the post-migration period is far more important with respect to psychopathology than pre-migration trauma. However, Beiser does not take into consideration the type of trauma. Ebert and Dyck (2004) argue that trauma which is persecutory in nature, such as torture, has the potential to engender PTSD as well as MDD (Ebert & Dyck, 2004).

The purpose of this paper is to examine how type of pre-migration trauma, post-migration stressors, and post-migration resources differentially predict PTSD and MDD symptomatology in Arab immigrant women who have been exposed to pre-migration trauma. Findings will clarify how much emphasis nurses should give to the pre and post-migration time periods during an assessment, whether type of pre-migration trauma assists with making differential diagnoses, and whether post-migration is a critical period for nursing intervention. A better understanding of these issues is critical for psychiatric nurses to develop, target, and time interventions that promote the mental health of immigrants.

PTSD, MDD, and Co-morbidity

Individual responses to trauma are varied. PTSD is but one potential long-term outcome that can manifest after exposure to a traumatic event (Yehuda, McFarlane, & Shalev, 1998). Additional possible outcomes include MDD without PTSD (e.g., Chapman, Whitfield, Felitti, Dube, Edwards, & Anda, 2004) as well as the co-morbidity of PTSD and MDD (e.g., Breslau, Davis, Peterson, & Schultz, 2000; Brown, Campbell, Lehman, Grisham, & Mancill, 2001). However, many individuals who are exposed to a traumatic event never develop PTSD or MDD (Yehuda, Halligan, Golier, Grossman, & Bierer 2004).

The factors contributing to differential responses to trauma are not well understood. In fact, there are contradictory findings. Research suggests that some aspects of HPA axis regulation in co-morbid PTSD-MDD are distinctly different from what is seen in “pure” MDD and “pure” PTSD (de Kloet, Vermetten, Lentjes, Geuze, van Pelt, Manuel, et al. 2008; Vythilingam, Gill, Luckenbaugh, Gold, Collin, Bonne, et al. 2010). Moreover, research regarding the sleep structure of individuals with PTSD, and co-morbid PTSD-MDD argue for more and different types of sleep disturbances in the latter group (Yetkin, Aydin, & Özgen, 2010). However, De kloet, et al (2008) conclude that symptom levels in these two groups are not sufficiently different to argue for co-morbid PTSD-MDD being distinctly different from PTSD. Their conclusions are consistent with research regarding individual differences in HPA axis regulation of cortisol levels and the DSM-IV field trial (Roth, Newman, Pelcovitz, van der Kolk, & Mandel, 1997). Their findings argue for MDD and PTSD representing two different biological responses to trauma (Yehuda, McFarlane, & Shalev, 1998), and for the differences between those who present with PTSD and those who present with co-morbid PTSD-MDD being small (Yehuda, et al, 2004), suggesting that co-morbid PTSD-MDD is a subtype of PTSD.

However, none of the research regarding PTSD-MDD comorbidity has focused on immigrants who have experienced persecution (e.g., torture). Pre-migration trauma are often of a persecutory nature and immigrants’ escape from persecution is typically followed by an intensive period of adjustment to a new country (Beiser, Turner, & Ganesan, 1989). As will be discussed next, there are theories and some evidence that suggest these considerations are important in determining whether individuals develop PTSD, MDD, or comorbid PTSD-MDD.

Predictors of Diagnostic Group Membership

Type of trauma clearly plays a role in the diverse pattern of responses to trauma: Traumatic experiences that include torture are associated with the highest incidence of PTSD (Yehuda, et al, 1998). Research documents this increased risk for PTSD in a variety of populations who have experienced torture, including Algerians, Ethiopians, and Gazans (WHO epidemiological survey, de Jong, Komproe, Ommeren, Masri, et al, 2001), Tibetan refugees (Holtz, 1998), Chilean and Salvadoran immigrants (Thompson & McGorry, 1995), and Vietnamese ex-political detainees (Mollica, McInnes, Pham, Fawzi, Murphy, & Lin 1998). This increase in the risk of PTSD has been observed even after controlling for demographic variables (Shrestha, Sharma, Van Ommeren, Regmi, Makaju, Komproe, Shrestha, & de Jong, 1998) and the effects of war and multiple trauma (Silove, Steel, McGorry, Miles, & Drobny, 2002).

According to Ebert and Dyck (2004), torture has great effects on psychopathology because it combines persecution with totalitarian control and organized violence. This combination potentially destroys trust and faith in humankind. Ebert and Dyck theorize that such experiences can create a loss of core beliefs and values, a sense of alienation, and an altered world view. These effects in turn increase the risk for both PTSD and depression symptoms (hopelessness, guilt, shame). Additionally, the self-in-relation to others is damaged, contributing to a social isolation which makes it difficult for the individual to participate in intimate relationships, further increasing the risk of developing MDD in addition to PTSD. Thus, we speculate that pre-migration experiences involving persecution (e.g., sectarian violence, torture) carry over and shape the post-migration period in ways that increase the risk for co-morbid PTSD-MDD.

Beiser’s (1999) position that the post-migration period has a far greater impact on immigrant mental health than pre-migration trauma is based on his longitudinal qualitative work with Asian immigrants. His position is also supported by ample studies that document a strong relationship between immigrant demands (e.g., loss, not feeling at home, novelty, occupation, language, and discrimination) and mental health outcomes (Aroian, Norris, Tran, & Schappler-Morris, 1998; Steel, Silove, Bird, McGory, et al., 1999; Tracy, 1999; Kimerling et al., 2004).

Beiser further asserts that the characteristics immigrants bring with them can mitigate risks to mental health and there is ample evidence that supports this assertion (Marsella, Friedman, Matthew, Spain, & Huland, 1996). For example, stress, an older age, and low education were all found to predict depressive symptoms in elderly Arab immigrants (Wrobel, Farraq & Hymes, 2009). However, none of this research has compared the relative impact of pre-migration trauma with these post-migration variables.

Social support has also been identified as a powerful protective factor with respect to immigrant mental health (Al-Issa, 1997; Beiser, 2006), particularly with respect to depression (Chou, 2009; Kuo, Chong, & Joseph, 2008). Social support appears to decrease the risk for depression in elderly women immigrants (e.g., Kuo, et al; Miller, Sorokin, Wang, Feetham, Choi, & Wilbur, 2006), as well as the risk for post-partum depression in younger women immigrants (e.g., Small, Lumley, & Yelland, 2003). However, the evidence linking social support to a decreased risk for PTSD is limited.

Arab immigrant women living in the US are an optimal group for investigating the effects of pre-migration persecution related trauma, and post-migration stressors and resources. Many of these women are from war-torn countries and have been persecuted because of political affiliation and ethnic/religious background (Jamil, Hakim-Larson, Farrag, Kafaji, Duqum, et al, 2002; Jamil, Hakim-Larson, Farrag, Kafaji, Jamil, et al, 2005). For example, Arab immigrants from both Lebanon and Iraq have firsthand experience with war and those from Iraq have also suffered sustained and systematic persecution during Sadam Hussein’s regime (Jamil, Nassar-McMillan, & Lambert, 2007).

Post-migration, Arab immigrant women may be the target of discrimination (Human Rights Watch, 2002; Naber, 2006), or experience other immigration related stressors (Wrobel Farrag, & Hymes, 2009). Arab women also have traditional cultural values that are more likely to be discordant with those in their host communities within the US, making adjustment more stressful (Al-Khawaja, 1997; Dwairy, 2006; Haddad & Smith, 1996).

The study that follows investigated the importance of type of trauma and post-migration stressors (immigration demands), resources (e.g., social support), demographic characteristics (education, youth) to the mental health of traumatized Arab women immigrants. The specific aims were to examine whether type of pre-migration trauma (persecution, e.g., torture), post-migration stressors (e.g., demands of immigration related to loss, not feeling at home, novelty, occupation, language, and discrimination), demographic characteristics (e.g., age, education), and social support are differentially predictors of diagnostic group membership (PTSD, MDD, co-morbid PTSD-MDD, subclinical symptoms).

Methods

Sample

Study participants were a subsample of Arab Muslim immigrant women living in metropolitan Detroit who were part of a larger study on mother – adolescent adjustment (Aroian, Hough, Templin, Kulwicki, Ramaswarmy & Katz, 2009). The subsample was selected from the larger study based on their endorsing having experienced one or more types of pre-migration trauma from Section 1 of the Posttraumatic Diagnostic Scale (PDS; Foa, 1995). This selection criterion yielded 519 study participants (81.6% of full sample). A majority of the resulting sample (72.5%) reported living through or witnessing three or more traumatic events. The most commonly reported types were military combat or war zone (92.9%); serious accident, fire, or explosion (70.9%); imprisonment (48.4%); life-threatening illness (39.5%); torture (37.8%); and natural disaster (31.4%). Very few (2.6%) reported experiencing physical or sexual assault not related to war or political/ethnic persecution.

The mean age of the sample was 40.22 (SD = 6.50) years with a range of 26.84 to 34.97 years. Most participants were married (84.6%). These characteristics reflect the fact that only women with one or more adolescents were eligible for participation in the larger study. Over half (54.1%) of the sample was born in Iraq and a third (33.1%) was born in Lebanon. The remaining 12.8% were born in 1 of 12 other Arab countries in the Middle East or Northern Africa. Median length of time living in the U.S. was 9.26 years. More had entered the U.S. as refugees (54.1%) or immigrants (38.3%), with only 7.5% entering on tourist, student, or work visas before seeking permanent residence. Only 18.8% spoke English. Almost two thirds (65.1%) had less than a high school education and only 9.3% had a college degree. The majority were homemakers who were not looking for work (96.3%). Only 16.2% were employed full or part-time. Of the 426 women who had husbands currently in the home (i.e., not widowed, divorced, or separated), 52.1% of their husbands were employed either full or part time. Almost half (43.5%) of the husbands had less than high school education, but 18.1% had a college degree.

Procedure

After receiving IRB approval from the university affiliated with the study, participants were recruited through verbal advertisement by bilingual research assistants who were also immigrants and representative of the countries of origin in the local Arab community. They could choose to be interviewed in English or Arabic, with almost all choosing Arabic (97%). Informed consent and data collection occurred in study participants’ homes. Bilingual research assistants verbally administered the measures. Every participant was given a list of Arabic-speaking mental health professionals to contact if they wished, but stronger recommendations were given to participants who exhibited high levels of distress. Participants were given $30.00 for their time.

Measures

Arabic language versions of study measures were developed through translation and back translation as a validity check, and further evaluated by committee consensus. The goal of the translation work was loyalty of meaning and equal familiarity and colloquialness in both languages (Werner and Campbell, 1970). Only measures used in the analyses reported here are described next. Age (youth) and education were captured using items from the study demographic and migration questionnaire.

Age was calculated using birth and interview dates. Education was dichotomized as less than high school (0, includes no education) and high school, its equivalent, or greater (1).

The Center for Epidemiology Screen-Depression (CES-D; Radloff, 1977) was used as a proxy measure for meeting diagnostic criteria for Major Depressive Disorder (MDD). The CES-D assesses the presence of 20 depressive symptoms, based upon how respondents felt during the past week. Items are scored from 0 (rarely) to 3 (most of all of the time) with a high score reflecting increased depressive symptomatology. Validity is supported and reliability coefficients are high (Cronbach’s alpha = .90) among general population samples (Radloff, 1977). Validity and reliability (alpha = .91) is supported for the Arabic language version used for the analyses presented here (Aroian, Kaskiri, et al, 2008; Ghubash, et al, 2000). For example scores on the CES-D were correlated with scores on the Profile of Mood State (POMS) subscale Depression/Dejection (r = .81; Aroian, Kulwicki, Kaskiri, Templin, & Wells, 2008). Cronbach’s alpha was .91 in this study sample.

A CES-D score of 16 can be used to estimate the prevalence of Major Depressive Disorder in a given population (Radoff, 1977). Support for use of this cutscore in an Arab sample is provided by Ghubash, Daradkew, Al Naseri, Al Bloushi, and Al Daheri (2000) in their study of college age Arab women living in the Middle East. Ghubash et al, found that 82% of those scoring above the cut-off were correctly classified as having MDD. Thus, individuals scoring 16 or higher on this measure in this sample were classified as having MDD for purposes of the study analyses.

The Posttraumatic Diagnostic Scale (PDS; Foa, 1995) was used as a proxy measure for meeting diagnostic criteria for PTSD (see also Table 1). The PDS is comprised of four sections. Section II, which asks which event has disturbed you the most in the past month, was not used and is not described here.

Table 1.

Correspondence between Foa’s (1995) PDS and the DSM-IV criteria for PTSD

Foa’s (1995) PDS DSM-IV Criteria for PTSD
Section I Criterion A: A traumatic experience
Section II Criterion B: At least 1 re-experiencing symptom
Criterion C: At least 3 avoidance symptoms
Criterion D: At least 2 arousal symptoms
Section III Criteria F: Problems with functioning

Sections I, III, and IV of the PDS correspond to the DSM-IV criteria A, B, C, D, and F for PTSD (Foa, 1995). Responses can be used to determine if the following are present: (1) a traumatic experience consistent with criterion A (Section 1); (2) symptoms consistent with DSM criteria B (Intrusive Recollection (AKA Re-experiencing Symptoms)), C (Avoidant/Numbing Symptoms (AKA Avoidance Symptoms)), and D (Hyperarousal (AKA Arousal Symptoms), Section III); and (3) problems with functioning consistent with DSM criteria F (Section IV).

Section I of the PDS contains a checklist of traumatic events. Respondents indicate whether they have experienced or witnessed each of these events or use the “other” category to write in events not included in the checklist. Traumatic events reported in Section I were used to categorize participants as having experienced a persecution type trauma (yes, no). Persecution type trauma was defined as torture or witnessing a family member being tortured, imprisonment, and/or home invasion. Non-persecution trauma was defined as war related or natural disaster related trauma.

Section III contains 17 items that assess the PTSD symptoms of Re-experiencing, Avoidance, and Arousal. The frequency of each symptom’s occurrence in the past month is rated on a four point scale, ranging from 0 (not at all or only one time) to 3 (five or more times a week or almost always). Reliability is excellent for both English (Foa, 1995) and Arabic (Norris & Aroian, 2008) language versions (Cronbach’s alpha = .93). Validity of the Arabic language version is supported by factor analysis and replication of the pattern of correlations obtained by Foa (e.g., correlations with measures of depression (r = .66) and stress (r = .55); Norris & Aroian, 2008). Cronbach’s alpha was .93 in this study sample.

Section IV assesses general satisfaction with life, functioning overall, and functioning in different life domains – work, home, family, etc. It contains nine items for which the response options are yes or no.

Zimit, Dahlem, Zimet, and Farley’s (1988) Multidimensional Scale of Perceived Social Support is a 12 item measure that assesses social support in three domains (friends, family, and significant others). Each item is rated along a 7-point scale ranging from very strongly disagree (1) to very strongly agree (7). For use with an Arab population, scale items that referred to “significant other” were modified to refer to “husband” because intimate or romantic relationships are only permissible between women and their spouses (Haddad & Smith, 1996). Items referring to family specified that they pertain to “family other than your spouse” to capture support from extended family. Extended family is an important source of support for Arabs and typically differs in form and function from spousal support (Kulwicki, 1996; Shryock, 2000). A total scale score is computed by summing the items responded to and dividing this sum by the number of items completed, allowing women who do not have a husband to have a total score based on the items that they completed. Internal consistency reliability (alpha = .74 (total scale)) for the Arabic language version (Aroian, Templin, & Ramaswamy, 2010) and original English version of total scale is satisfactory (e.g., Dahlem, Zimet & Walker, 1999; Kazarian & McCabe, 1991; Zimet, et al, 1988). Support for the validity of the Arabic language version is demonstrated by replication of the original factor structure and the pattern of correlations between the subscales and emotional distress, types of hassles, and coping behaviors (Aroian, et al, 2010). Cronbach’s alpha for the total scale was .75 in this study sample.

The Demands of Immigration Scale (DI) is a 23- item measure that elicits information about immigration stressors related to loss, not feeling at home, novelty, occupation, language, and discrimination (Aroian, et al, 1998). Respondents rate, along a 6-point scale ranging from 0 (not at all) to 5 (very much), the extent to which they have been distressed by each of the stated demands as it applies to their recent (within the last 3 months) personal experiences as immigrants. Higher scores represent greater immigration demands. Reliability and construct validity of the DI Scale have been established with Russian (Aroian et al., 1998) and Arab immigrants (Aroian, Kaskiri, & Templin, 2008). Confirmatory factor analysis supports a six-factor as well as higher, single-factor model. The correlation between the DI and DeLongis, Folkman, and Lazarus (1988)’s Daily Hassles scale (r = .65) in the current study population provides additional support for validity of the measure (Aroian, et al., 2008). Although the DI measures subjective distress, the measurement model developed via confirmatory factor analysis for the larger study confirmed that the DI is conceptually distinct from the CES-D (Aroian et. al., 2009). Cronbach’s alpha for the Arabic language version of the DI was .86 for total scale in this study sample.

Data Analysis

First, participants were classified into one of four groups on the basis of their responses to the PDS and CES-D: Subclinical, PTSD, MDD, or Co-Morbid PTSD-MDD. The term “Subclinical” was used because these women tended to have symptoms, but not at a sufficiently high enough level to be consistent with what would be seen in MDD or PTSD.

Second, multinomial regression analysis was used to investigate whether trauma type, post-migration stressors (e.g., demands of immigration related to loss, not feeling at home, novelty, occupation, language, and discrimination), demographic characteristics (e.g., age, education), and social support differentially predict diagnostic group membership (PTSD, MDD, comorbid PTSD-MDD, Subclinical). The Co-Morbid PTSD-MDD was used as the reference group in this analysis. There was no evidence of multicollinearity (largest correlation between the independent variables was −.21)

The multinomial regression analyses reported here were conducted with and without controlling for length of time in the United States. Inclusion of the length of time in the US in any of these analyses had little or no effect on the magnitude or significance tests of the regression coefficients (i.e., did not substantively alter them). Hence results of these additional analyses are not reported here.

The stability of the parameter estimates, despite the small size of the PTSD only group, is supported by similarities in the coefficients produced when the PTSD only group was alternatively included and excluded from the analyses. However, the small size of the PTSD only group limits the sensitivity of the parameter tests for comparisons involving the PTSD only group (the standard error for this group is very large due to its small size). This increases the risk for Type II error with respect to these comparisons.

Results

As can be seen from the descriptive statistics in Table 2, more than half (57.03%) of the sample had scores above 16 on the CES-D. Almost half (45.27%) of women with CES-D scores above 16 (25.82% of the total sample) had PDS scores consistent with PTSD. Less than 5% of the study sample had PDS scores consistent with PTSD but CES-D scores inconsistent with MDD.

Table 2.

Classification of symptom groups in study sample

PTSD Criteria Met on PDS? Row Totals: (n = 519)

No Yes

CES-D responses consistent with MDD? No Subclinical PTSD
40.27% (n = 209) 2.70% (n = 14) 42.97% (n = 223)
Yes MDD Co-Morbid PTSD-MDD
31.21% (n = 162) 25.82% (n = 134) 57.03% (n = 296)
Column Totals: (n = 519) 71.48% (n = 371) 28.51% (n = 148)

All predictor variables with the exception of education (Wald Chi-Square = 5.66, df = 3, p = .13) were significant in the multinomial regression analyses. Post-immigration related stressors (as captured by the Demands of Immigration measure) had the strongest effect in the analysis (Wald Chi-Square = 72.90, df = 3, p < .0001), followed by social support (Wald Chi-Square = 19.91, df = 3, p < .001). Both age (Wald Chi-Square = 9.60, df = 3, p < .05) and exposure to trauma involving persecution (Wald Chi-Square = 8.93, df = 3, p < .05) had significant but smaller effects.

The parameter estimates and odds ratios (ORs) for each group compared against the Co-Morbid PTSD-MDD reference group are depicted in Table 3. Inspection of these estimates and ORs indicates that a unit increase in the Demands of Immigration score is associated with a nearly 17 fold increase in the likelihood of being in the Co-Morbid group relative to the Subclinical group, and a nearly 2.5 increase in the likelihood of being in the Co-Morbid group relative to the MDD only group relative to the. Both of these effects remained significant after applying a Bonferonni correction (p < .05).

Table 3.

Maximum Likelihood Estimates and Odds Ratios from multinomial regression.

Parametera Group B Std. Error Odds Ratio (OR) Significanceb
Intercept Subclinical 4.0062 1.0819 _ _ _ _ .0002*
MDD only 3.3821 1.0117 _ _ _ _ .0008*
PTSD only −1.8330 2.8489 _ _ _ _ .5200
Age Subclinical −.0541 .0193 .947 .0050*
MDD only −.0402 .0180 .961 .0256
PTSD only −.0802 .0492 .923 .1028
Education Subclinical .5952 .2896 1.813 .0398
MDD only .6186 .2786 1.856 .0264
PTSD only .6571 .6137 1.929 .2843
Demands of Immigration Subclinical −2.7487 .3251 .064 < .0001*
MDD only −.8879 .2589 .412 .0006*
PTSD only −.8555 .6549 .425 .1915
Social Support Subclinical .3620 .1126 1.436 .0013*
MDD only −.0346 .0981 .966 .7244
PTSD only .6660 .3140 1.946 .0339
Trauma with Persecution Subclinical −.7830 .2721 .457 .0040*
MDD only −.5770 .2630 .561 .0281
PTSD only −.1490 .6339 .862 .8141
a

Reference group is the Co-Morbid PTSD-MDD group.

b

Asterisk indicates parameter is significant at p < .05 with Bonferroni correction.

Parameter estimates for Social Support indicate that each increment in the Social Support score, the odds of being in the subclinical group and the PTSD only group relative to being in the Co-Morbid group increase by a factor of 1.4 to 1.5 (p < .05; see Table 3). However, only the estimate comparing the Subclinical group remained significant after applying a Bonferonni correction (p < .05).

Findings in Table 3 also indicate that experiencing a trauma involving persecution in the pre-migration period appears to more than double the odds of being in the Co-Morbid group relative to the Subclinical group. This type of trauma experience also appears to nearly double the odds of being in the Co-Morbid relative to the MDD only group (p < .05). However, only the former estimate comparing the Subclinical group remained significant after applying a Bonferonni correction (p < .05).

Consistent with a protective effect for youth, age appears to increase the odds of having Co-morbid PTSD-MDD relative to being in the Subclinical or MDD only group. However, this effect is only significant for the Subclinical group after a Bonferonni correction. The small ORs for age (ORs are close to 1) and the small Wald Square (Wald Chi-Square = 9.60, df = 3, p < .05) for the overall effect of age are both consistent with the small differences in mean ages shown in Table 4.

Table 4.

Group values for study variablesa

Subclinical (n = 209) PTSD (n = 14) MDD (n =162) Co-Morbid PTSD-MDD (n = 134)
Age (n=200) (n = 14) (n =150) (n = 131)
 Mean 39.44 years 38.52 years 40.00 years 41.86 years
 (SD) (6.21) (4.48) (6.34) (7.03)
Education (n = 209) (n = 14) (n =162) (n =134)
 Less than High School (H.S.) 57.0% 64.3% 64.2% 79.7%
 H.S. Grad., Equivalent or beyond 43.0% 35.7% 35.8% 20.3%
Demands of Immigration (n = 209) (n = 14) (n = 157) (n = 134)
 Mean .86 1.20 1.18 1.41
 (SD) (.40) (.35) (.47) (.49)
Social Support (n = 209) (n = 14) (n = 157) (n = 134)
 Mean 5.68 6.06 5.26 5.31
 (SD) (1.08) (.99) (1.24) (1.34)
Trauma with Persecution (n = 209) (n = 14) (n = 157) (n = 134)
 No (War Zone, Natural Disaster) 48.1% 28.6% 38.9% 26.3%
 Yes (Persecution) 51.9% 71.4% 61.1% 73.7%
a

Bonferroni corrected significance tests for parameter estimates in the multinomial regression indicate means and frequencies reported for the Co-Morbid PTSD-MDD group are significantly different from those reported for the Subclinical group for all study variables except Education (p < .05). In addition, these significance tests indicate that the mean Demands of Immigration scores for the Co-Morbid PTSD-MDD group are significantly different from those reported for the MDD only group (p < .05).

Discussion

This study examined the impact of type of trauma experienced during the pre-migration period, and post-migration stressors and resources on PTSD and MDD symptomatology in Arab immigrant women living in the United States. Study findings support Beiser’s (1998) argument as to the importance of the post-migration period to immigrant mental health. Immigration related stressors were strongly associated with being in the Co-Morbid PTSD-MDD group relative to the Subclinical symptom group. Type of trauma did increase the odds of being in the Co-Morbid relative to the Subclincal Symptoms group. However, the odds ratios for immigration related stressors were much larger than that observed for pre-migration trauma that involved persecution. Thus our findings replicate qualitative (e.g., Beiser, 1999) and quantitative findings (e.g., Steel, et al, 1999) in the literature regarding the impact of post-migration stressors and they extend these findings by quantifying the impact of immigration related stressors in the context of pre-migration trauma and other post-migration resources.

Unfortunately, our ability to differentially predict PTSD and MDD symptoms was limited by the size of the PTSD only sample subgroup. The presence of high levels of PTSD symptoms in the absence of MDD symptoms was relatively rare in this sample of multiply traumatized Arab immigrant women. As a result our ability to detect differences between this group and the Co-Morbid PTSD-MDD group was underpowered. It is possible that lower levels of social support may differentiate between PTSD only and Co-Morbid PTSD-MDD symptomatology. This would mean that higher levels of social support protect against the development of high levels of MDD symptomatology which would be consistent with research and theory about role of social support in depression (e.g., Ayers, Hofstetter, Usita, Irvin, Kang & Hovell, 2009; Hovey & King, 1997; Kim, Han, Shin, Kim, & Lee, 2005). However, findings from the present study are inconclusive given the competing concerns of Type I and Type II error rates.

Our findings regarding the importance of resources (youth, education, social support) during the post-migration period are mixed. Consistent with previous research involving immigrants from other countries, we found that youth and social support decreased the risk for mental health problems (i.e., decreased the odds of being in the Co-Morbid PTSD-MDD group). However, contrary to past research, we found no significant effects for education.

Our participants tended to have limited ranges for education (the majority had less than a high school level of education) and age (26.84 to 34.97 years). This may have impeded our ability to detect effects for both of these variables. It is possible that both education and youth may play a more protective role in groups where there is a broader range for these variables.

There are at least three potential explanations for the small effect for social support that we observed here. First, the lack of a strong effect for social support may reflect the lesser importance of this variable in the context of other variables included in our analyses (immigration demands, persecution, etc.). Second, the small effect we obtained for social support may argue for better measures of social support. It is possible that the measure we used did not fully capture social support or those aspects of social support that are relevant to MDD and PTSD psychopathology. Third, it is likely that the social support system available for these women was comprised of individuals who were similarly traumatized and thus unable to serve as an effective resource. Considering the language barriers and the size of the ethnic enclave in the city of Detroit where these women lived, it is probable that their social support system consisted of other Arab immigrant women. The high reports of traumatic experiences in the full study population from which this study subsample was drawn, and the high incidence of depression and PTSD noted in this subsample argue for the last explanation. Thus, we are reluctant to conclude on the basis of these study findings alone that social support is not an important variable to study in the context of trauma exposed Arab immigrant women’s post-migration mental health.

This study has at least three limitations. First, these data are cross-sectional. It is unclear how current mood states impacted reporting of past events or current levels of stress. Therefore, replication of these findings with longitudinal data is needed.

Second, all of our study participants were Arab women, and the majority of this sample was married. Hence, our study results are not directly generalizable to Arab men and it is possible that these results would differ in a sample of widowed, divorced, separated or never married women as well as women from other cultural/ethnic groups. However, our results are consistent with those of Wrobel, et al (2009)’s findings of an effect for stress and older age on depressive symptoms in elderly Arab male and female immigrants. This suggests these findings may have some generalizability to elderly Arab immigrants.

Finally, and most importantly, we were not able to create our subgroups on the basis of formal diagnostic evaluations provided by a psychiatric clinician. Instead, we relied on self-report of symptoms. Also, our definition of individuals meeting symptom criteria for MDD was based on responses to a screening tool rather than a diagnostic measure. It is possible that the MDD group contained individuals who would not have met diagnostic criteria for MDD upon further clinical examination. If so, this would have biased the proportion we observed in the MDD group in a lower direction. However, the percentage of women who met symptom criteria for MDD and also reported symptom levels consistent with PTSD in this study (45.3%) is similar to what was observed for women participants in the National Co-morbidity Study (48.5%, Kessler, Sonnega, Bromet, Hughes, & Nelson 1995). This provides some support for the validity of our findings, but clearly research is needed with community populations of immigrants that use formal diagnostic procedures to identify individuals with and without MDD, PTSD, and co-morbid PTSD-MDD. Specifically, more research is needed using (a) procedures such as a Structured Clinical Interview of DSM-I-R Mental Disorders (SCID; Spitzer, Williams, Gibbon, & First. 1990) to diagnose participants with MDD and PTSD, and (b) samples with larger numbers of individuals who meet diagnostic criteria for PTSD but not MDD. Such research would allow us to more conclusively rule out (or rule in) a link between persecution type trauma and co-morbid PTSD-MDD as compared to PTSD only symptomatology.

Despite these limitations, study findings have implications for theory, practice and research. With respect to theory, these findings argue for the importance of what happens after the trauma. Greater understanding is needed of the physiological mechanisms by which life stressors in the post-event period contribute to the development of PTSD and depression in immigrant populations with a trauma history.

With respect to practice, these findings argue for psychiatric nurses discussing post-migration experiences with their clients and teaching stress management skills. The post-migration period appears to be a critical period for nursing intervention with respect to immigration related stressors.

These findings also argue that psychiatric nurses should expect to treat Co-morbid PTSD-MDD more frequently than PTSD in isolation when working with immigrant clients with a trauma history. Unfortunately, it remains unclear whether type of trauma, particularly trauma involving persecution, is relevant to differentially predicting Co-Morbid PTSD-MDD from MDD or PTSD occurring in isolation.

These findings clearly argue for nurses to screen Arab immigrant women for depression and PTSD in primary care as well as psychiatric care settings. Slightly more than half of this sample had scores greater than 16 on the CES-D, and slightly more than a fourth appeared to meet the DSM IV-R symptom criteria for PTSD based on symptom self-report. However, these women were recruited from the community, not a clinical sample, suggesting it is important to screen Arab immigrant women at non-psychiatric health care encounters to ensure referral to appropriate treatment resources.

Finally, these findings identify directions for the research needed to guide nursing practice. Nursing interventions designed to support and assist patients in their management of immigration related stressors are clearly needed. Youth may be a protective factor, but our study findings suggest that the mental health of younger immigrants may be at risk in the context of immigration related stressors.

Our findings also underscore the need for more basic research regarding mental health and resilience. All of the women in this sample were at risk for depression and PTSD given their trauma history and the stressors associated with being an immigrant. However, not all of these women appeared to meet symptom criteria for these two illnesses. Slightly less than half (41.4%) had CES-D and PDS scores that argued against their symptom levels being consistent with MSS or PTSD. We found substantive negative effects for immigration related stressors and a smaller positive effect for social support, but clearly other factors play a role beyond what was studied here. This argues for future research regarding biological and social factors that contribute to resilience in women who are at high risk for developing a mental illness due to their life circumstances.

Acknowledgments

This study was funded by a grant from the National Institutes of Health, NR 008504, to Dr. Karen J. Aroian.

Contributor Information

Anne E. Norris, College of Nursing, University of Central Florida, Orlando, FL.

Karen J. Aroian, College of Nursing, University of Central Florida, Orlando, FL.

David Nickerson, Dept of Statistics, College of Sciences, University of Central Florida, Orlando, Florida.

References

  1. Al-Issa I. General issues and research problems. In: Al-Issa I, Tousignant M, editors. Ethnicity, Immigration, and Psychopathology. New York: Plenum; 1997. pp. 277–289. [Google Scholar]
  2. Al-Khawaja JMA. Impact of traumatic events on the psychological well-being of Kuwaitis who lived in Egypt and England during the Iraqi Invasion of Kuwait. Derasat Nafseyyah. 1997;7(4):628–641. [Google Scholar]
  3. Aroian K. Immigrant women and their health. Annual Review Of Nursing Research. 2001;19:179–226. [PubMed] [Google Scholar]
  4. Aroian KJ, Hough ES, Templin TN, Kaskiri EA. Development and Psychometric Evaluation of an Arab Version of the Family Peer Relationship Questionnaire. Research in Nursing and Health. 2008;31:402–416. doi: 10.1002/nur.20277. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Aroian KA, Hough E, Templin T, Kulwicki A, Ramaswarmy V, Katz A. A model of mother-child adjustment in Arab Muslim immigrants to the U.S. Social Science and Medicine. 2009;69:1377–1386. doi: 10.1016/j.socscimed.2009.08.027. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Aroian KJ, Kaskiri EA, Templin TN. Psychometric evaluation of the Arabic language version of the Demand of Immigration Scale. International Journal of Testing. 2008;8(1):2–13. [Google Scholar]
  7. Aroian KJ, Norris AE, Tran TV, Schappler-Morris N. Development and psychometric evaluation of the Demands of Immigration Scale. Journal of Nursing Measurement. 1998;6(2):175–194. [PubMed] [Google Scholar]
  8. Aroian KJ, Templin TN, Ramaswamy V. Adaptation and psychometric evaluation of the Multidimensional Scale of Perceived Social Support for Arab Immigrant Women. Health Care for Women International. 2010;31:153–169. doi: 10.1080/07399330903052145. [DOI] [PubMed] [Google Scholar]
  9. Ayers J, Hofstetter C, Usita P, Irvin V, Kang S, Hovell M. Sorting out the competing effects of acculturation, immigrant stress, and social support on depression: a report on Korean women in California. The Journal Of Nervous And Mental Disease. 2009;197(10):742–747. doi: 10.1097/NMD.0b013e3181b96e9e. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Beiser M. Influences of time, ethnicity, and attachment on depression in Southeast Asian refugees. American Journal of Psychiatry. 1988;145:45–61. doi: 10.1176/ajp.145.1.46. [DOI] [PubMed] [Google Scholar]
  11. Beiser M. Strangers at the Gate: The “Boat People’s” First Ten Years in Canada. Toronto, Ontario, Ganada: University of Toronto Press; 1999. [Google Scholar]
  12. Beiser M. Longitudinal research to promote effective refugee resettlement. Transcultural Psychiatry. 2006;43(1):56–71. doi: 10.1177/1363461506061757. [DOI] [PubMed] [Google Scholar]
  13. Beiser M, Turner RJ, Ganesan S. Catastrophic stress and factors affecting its consequences among Southeast Asian refugees. Social Science & Medicine. 1989;28:183–95. doi: 10.1016/0277-9536(89)90261-x. [DOI] [PubMed] [Google Scholar]
  14. Breslau N, Davis GC, Peterson EL, Schultz LR. A second look at comorbidity in victims of trauma: the posttraumatic stress disorder-major depression connection. Biological Psychiatry. 2000;48:902–909. doi: 10.1016/s0006-3223(00)00933-1. [DOI] [PubMed] [Google Scholar]
  15. Brown TA, Campbell LA, Lehman CL, Grisham JR, Mancill RB. Current and lifetime comorbidity of the DSM-IV anxiety and mood disorders in a large clinical sample. Journal of Abnormal Psychology. 2001;110:585–599. doi: 10.1037//0021-843x.110.4.585. [DOI] [PubMed] [Google Scholar]
  16. Chapman DP, Whitfield CL, Felitti VJ, Dube SR, Edwards VJ, Anda RF. Adverse childhood experiences and the risk of depressive disorders in adulthood. Journal of Affective Disorders. 2004;82:217–225. doi: 10.1016/j.jad.2003.12.013. [DOI] [PubMed] [Google Scholar]
  17. Chou K. Pre-migration planning and depression among new migrants to Hong Kong: the moderating role of social support. Journal of Affective Disorders. 2009;114(1–3):85–93. doi: 10.1016/j.jad.2008.06.005. [DOI] [PubMed] [Google Scholar]
  18. Davis R. Refugee experiences and Southeast Asian women’s mental health. Western Journal of Nursing Research. 2000;22(2):144–162. doi: 10.1177/01939450022044331. [DOI] [PubMed] [Google Scholar]
  19. de Jong JTM, Komproe IH, Ommeren MV, Masri ME, Araya M, Khaled N, et al. Lifetime events and posttraumatic stress disorder in 4 conflict settings. Journal of the American Medical Association. 2001;286:555–562. [Google Scholar]
  20. de Kloet C, Vermetten E, Lentjes E, Geuze E, van Pelt J, Manuel R, Heijnen C, Westenberg H. Differences in the response to the combined DEX-CRH test between PTSD patients with and without co-morbid depressive disorder. Psychoneuroendocrinology. 2008;33(3):313–320. doi: 10.1016/j.psyneuen.2007.11.016. [DOI] [PubMed] [Google Scholar]
  21. DeLongis A, Folkman S, Lazarus RS. The impact of daily stress on health and mood: Psychological and social resources as mediators. Journal of Personality and Social Psychology. 1988;54:454–460. doi: 10.1037//0022-3514.54.3.486. [DOI] [PubMed] [Google Scholar]
  22. Dwairy M. Counseling and psychotherapy with Arabs and Muslims. New York: Teachers College Press; 2006. [Google Scholar]
  23. Dahlem NW, Zimet GD, Walker RR. The Multidimensional Scale of Perceived Social Support: A confirmation study. Journal of Clinical Psychology. 1999;47:756–761. doi: 10.1002/1097-4679(199111)47:6<756::aid-jclp2270470605>3.0.co;2-l. [DOI] [PubMed] [Google Scholar]
  24. Ebert A, Dyck MJ. The experience of mental death: The core feature of complex posttraumatic stress disorder. Clinical Psychology Review. 2004;24:617–635. doi: 10.1016/j.cpr.2004.06.002. [DOI] [PubMed] [Google Scholar]
  25. Foa EB. Posttraumatic stress diagnostic scale manual. Minneapolis, MN: NCS Pearson, Inc; 1995. [Google Scholar]
  26. Ghubash R, Daradkeh TK, Al-Naseri KS, Al-Bloushi NB, Al-Daheri AM. The performance of the Center for Epidemiologic Study Depression Scale (CES-D) in an Arab female community. International Journal of Social Psychiatry. 2000;46(4):241–249. doi: 10.1177/002076400004600402. [DOI] [PubMed] [Google Scholar]
  27. Haddad YY, Smith JI. Islamic values among American Muslims. In: Aswad B, Bilge B, editors. Family and gender among American Muslims: Issues facing Middle Eastern and immigrants and their descendants. Philadelphia: Temple University Press; 1996. pp. 19–41. [Google Scholar]
  28. Holtz TH. Refugee trauma versus torture trauma: A retrospective controlled cohort study of Tibetan Refugees. Journal of Nervous and Mental Disease. 1998;186:24–34. doi: 10.1097/00005053-199801000-00005. [DOI] [PubMed] [Google Scholar]
  29. Hovey JD, King CA. Suicidality among acculturating Mexican Americans: Current knowledge and directions for research. Suicide and Life-Threatening Behavior. 1997;27(1):92–103. [PubMed] [Google Scholar]
  30. Jamil H, Hakim-Larson J, Farrag M, Kafaji T, Jamil L, Hammad A. Medical complaints among Iraqi American refugees with mental disorders. Journal of Immigrant Health. 2005;7(3):145–152. doi: 10.1007/s10903-005-3671-z. [DOI] [PubMed] [Google Scholar]
  31. Jamil H, Hakim-Larson J, Farrag M, Kafaji T, Duqum I, Jamil LH. A retrospective study of Arab American mental health clients: Trauma and the Iraqi refugees. American Journal of Orthopsychiatry. 2002 Jul;72(3):355–361. doi: 10.1037/0002-9432.72.3.355. [DOI] [PubMed] [Google Scholar]
  32. Jamil H, Nassar-McMillan S, Lambert R. Immigration and attendant psychological sequelae: a comparison of three waves of Iraqi immigrants. The American Journal Of Orthopsychiatry. 2007;77(2):199–205. doi: 10.1037/0002-9432.77.2.199. [DOI] [PubMed] [Google Scholar]
  33. Kazarian SS, McCabe SB. Dimensions of Social Support in the MSPSS: Factorial Structure, Reliability, and Theoretical Implications. Journal of Community Psychology. 1991;19:150–160. [Google Scholar]
  34. Kessler RC, Sonnega A, Bromet E, Hughes M, Nelson CB. Posttraumatic stress disorder in the National Comorbidity Survey. Archives of General Psychiatry. 1995;52(12):1048–1060. doi: 10.1001/archpsyc.1995.03950240066012. [DOI] [PubMed] [Google Scholar]
  35. Kim M, Han H, Shin H, Kim K, Lee H. Factors associated with depression experience of immigrant populations: a study of Korean immigrants. Archives Of Psychiatric Nursing. 2005;19(5):217–225. doi: 10.1016/j.apnu.2005.07.004. [DOI] [PubMed] [Google Scholar]
  36. Kimerling R, Prins A, Westrup D, Lee T. Gender Issues in the Assessment of PTSD. In: Wilson JP, Keane’s TM, editors. Assessing Psychological Trauma and PTSD. 2. New York, N.Y: The Guilford Press, N.Y; 2004. pp. 565–599. [Google Scholar]
  37. Kuo B, Chong V, Joseph J. Depression and its psychosocial correlates among older Asian immigrants in North America: a critical review of two decades’ research. Journal of Aging And Health. 2008;20(6):615–652. doi: 10.1177/0898264308321001. [DOI] [PubMed] [Google Scholar]
  38. Kulwicki A. The Arab family. In: Julia M, editor. Multicultural awareness in the health care professions. Boston: Allyn and Bacon; 1996. pp. 59–76. [Google Scholar]
  39. Marsella A, Friedman M, Spain E. Ethnocultural aspects of PTSD: An overview of issues and research directions. In: Marsella A, Friedman M, Gerrity E, Scurfield RM, editors. Ethnocultural aspects of posttraumatic stress disorder: Issues, research, and clinical applications. Washington, DC US: American Psychological Association; 1996. pp. 105–129. [Google Scholar]
  40. Mollica R, McInnes K, Pham T, Fawzi M, Murphy E, Lin L. The dose–effect relationships between torture and psychiatric symptoms in Vietnamese ex-political detainees and a comparison group. Journal of Nervous and Mental Disease. 1998;186(9):543–553. doi: 10.1097/00005053-199809000-00005. [DOI] [PubMed] [Google Scholar]
  41. Miller A, Sorokin O, Wang E, Feetham S, Choi M, Wilbur J. Acculturation, social alienation, and depressed mood in midlife women from the former soviet union. Research in Nursing and Health. 2006;29(2):134–146. doi: 10.1002/nur.20125. [DOI] [PubMed] [Google Scholar]
  42. Naber N. The rules of forced engagement: Race, gender, and the culture of fear among Arab immigrants in San Francisco post-9/11. Culture Dynamics. 2006;18(3):235–276. [Google Scholar]
  43. Norris AE, Aroian KJ. Assessing Reliability and Validity of the Arabic Language Version of the Posttraumatic Diagnostic Scale (PDS) Symptom Items. Psychiatry Research. 2008;160(3):327–34. doi: 10.1016/j.psychres.2007.09.005. [DOI] [PMC free article] [PubMed] [Google Scholar]
  44. Radloff L. The CES-D scale: A self-report depression scale for research in the general population. Applied Psychological Measurement. 1977;1:385–401. [Google Scholar]
  45. Robjant K, Robbins I, Senior V. Psychological distress amongst immigration detainees: A cross-sectional questionnaire study. The British Journal of Clinical Psychology/The British Psychological Society. 2009;48(Pt 3):275–286. doi: 10.1348/014466508X397007. [DOI] [PubMed] [Google Scholar]
  46. Roth S, Newman E, Pelcovitz D, van der Kolk B, Mandel FS. Complex PTSD in victims exposed to sexual and physical abuse: Results from the DSM-IV Field Trial for Posttraumatic Stress Disorder. Journal of Traumatic Stress. 1997;10(4):539–555. doi: 10.1023/a:1024837617768. [DOI] [PubMed] [Google Scholar]
  47. Shrestha NM, Sharma B, Van Ommeren M, Regmi S, Makaju R, Komproe I, Shrestha GB, de Jong JTM. Impact of torture on refugees displaced within the developing world symptomatology among Bhutanese refugees in Nepal. JAMA. 1998;280:443–448. doi: 10.1001/jama.280.5.443. [DOI] [PubMed] [Google Scholar]
  48. Shryock A. Family resemblances: Kinship and community in Arab Detroit. In: Abraham N, Shryock A, editors. Arab Detroit From Margin to Mainstream. Detroit, MI: Wayne State University Press; 2000. pp. 573–611. [Google Scholar]
  49. Silove D, Steel Z, McGorry P, Miles V, Drobny J. The impact of torture on post-traumatic stress symptoms in war-affected Tamil refugees and immigrants. Comprehensive Psychiatry. 2002;43(1):49–55. doi: 10.1053/comp.2002.29843. [DOI] [PubMed] [Google Scholar]
  50. Small R, Lumley J, Yelland J. Cross-cultural Experiences of Maternal Depression: Associations and Contributing Factors for Vietnamese, Turkish and Filipino Immigrant Women in Victoria, Australia. Ethnicity and Health. 2003;8(3):189–206. doi: 10.1080/1355785032000136416. [DOI] [PubMed] [Google Scholar]
  51. Spitzer RL, Williams JBW, Gibbon M, First MB. Structured Clinical Interview for DSM-II-R. American University Press; Washington DC: 1990. [Google Scholar]
  52. Steel Z, Silove D, Bird K, McGorry P, Mohan P. Pathways from war trauma to posttraumatic stress symptoms among Tamil asylum seekers, refugees, and immigrants. Journal of Traumatic Stress. 1999;12(3):421–435. doi: 10.1023/A:1024710902534. [DOI] [PubMed] [Google Scholar]
  53. Thompson M, McGorry P. Psychological sequelae of torture and trauma in Chilean and Salvadorean migrants: A pilot study. Australian and New Zealand Journal of Psychiatry. 1995;29(1):84–95. doi: 10.3109/00048679509075896. [DOI] [PubMed] [Google Scholar]
  54. Tracy LC. Immigrant Women’s Health Problems Solutions. Jossey-Bass, Inc; San Francisco, CA: 1999. Posttraumatic Stress Disorder; pp. 220–395. [Google Scholar]
  55. Werner O, Campbell DT. Translating, working through interpreters and the problem of decentering. In: Naroll R, Chen R, editors. A handbook of method in cultural anthropology. Columbia University Press; New York City, NY: 1970. pp. 398–420. [Google Scholar]
  56. Wrobel N, Farrag M, Hymes R. Acculturative stress and depression in an elderly Arabic sample. Journal of Cross-Cultural Gerontology. 2009;24(3):273–290. doi: 10.1007/s10823-009-9096-8. [DOI] [PubMed] [Google Scholar]
  57. Vythilingam M, Gill J, Luckenbaugh D, Gold P, Collin C, Bonne O, et al. Low early morning plasma cortisol in posttraumatic stress disorder is associated with co-morbid depression but not with enhanced glucocorticoid feedback inhibition. Psychoneuroendocrinology. 2010;35(3):442–450. doi: 10.1016/j.psyneuen.2009.08.006. [DOI] [PubMed] [Google Scholar]
  58. Yehuda R, Halligan S, Golier J, Grossman R, Bierer L. Effects of trauma exposure on the cortisol response to dexamethasone administration in PTSD and major depressive disorder. Psychoneuroendocrinology. 2004;29(3):389–404. doi: 10.1016/s0306-4530(03)00052-0. [DOI] [PubMed] [Google Scholar]
  59. Yehuda R, McFarlane A, Shalev A. Predicting the development of posttraumatic stress disorder from the acute response to a traumatic event. Biological Psychiatry. 1998;44(12):1305–1313. doi: 10.1016/s0006-3223(98)00276-5. [DOI] [PubMed] [Google Scholar]
  60. Yetkin S, Aydin H, Özgen F. Polysomnography in patients with post-traumatic stress disorder. Psychiatry and Clinical Neurosciences. 2010;64(3):309–317. doi: 10.1111/j.1440-1819.2010.02084.x. [DOI] [PubMed] [Google Scholar]
  61. Zimet GD, Dahlem NW, Zimet SG, Farley GK. The Multidimensional Scale of Perceived Social Support. Journal of Personality Assessment. 1988;52(1):30–41. doi: 10.1080/00223891.1990.9674095. [DOI] [PubMed] [Google Scholar]

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