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. Author manuscript; available in PMC: 2016 Aug 1.
Published in final edited form as: Biomaterials. 2015 May 19;61:162–177. doi: 10.1016/j.biomaterials.2015.05.028

Figure 7. Histology images evaluating features of arthritis.

Figure 7

Represents the Masson Trichrome stained sections of the fore and hind paws of the rats dosed i.p. with various treatment groups containing 100μg of murine IL-10 plasmid DNA at day 18 (A) and day 28 (B), post-adjuvant administration. Classical features of arthritis such as pannus formation (P), high osteoclast activity (O), cellular infiltration (C), and joint space narrowing (JS) are indicated with arrows/symbols in the two panels. pDNA-Plasmid DNA. Images are representive of n=3 rats per treatment group. NP = nanoparticle formulation. Scale Bar = 400μm.