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. Author manuscript; available in PMC: 2016 Jun 9.
Published in final edited form as: Circulation. 2015 Jun 9;131(23):2079–2091. doi: 10.1161/CIRCULATIONAHA.114.006980

Figure 6.

Figure 6

Angiotensin II type-1 receptor (AT1R) inhibition improves hemodynamics in pulmonary arterial hypertension (PAH). (A) Expression levels of AT1R are increased in pulmonary arterioles harvested from patients with idiopathic PAH compared to controls. (B) Inhibition of AT1R with losartan (20 mg/kg) improves RV systolic pressure (left) and pulmonary vascular resistance (right) in monocrotaline-PAH. Reprinted from Ref. 60 with permission of the American Thoracic Society. Copyright ©2014 American Thoracic Society