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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Hypertension. 2015 Apr 27;66(1):211–220. doi: 10.1161/HYPERTENSIONAHA.115.05332

Figure 1. Effect of PPARγ Activation.

Figure 1

A) Mice treated with pioglitazone and their controls had significant increases in systolic blood pressure. In the control group, the increase in blood pressure was significant at week 1, 2 and 3 when compared to baseline. In the pioglitazone group, there was an increase in blood pressure that was not significant when at week 1 and 2 when compared to baseline. However, at week 3, the increase in blood pressure was significant when compared to baseline. B) The incidence of aneurysm formation in both C57BL/6 control group and pioglitazone group was not significantly different. C) The incidence of aneurysm rupture and SAH in C57BL/6 control group and pioglitazone group. Pioglitazone had a tendency to decrease the incidence of aneurysm rupture, but this was not statistically significant. D) Kaplan Meier analysis of the survival in the pioglitazone group and its control. No significant difference was noted in Kaplan Meier analysis when comparing pioglitazone to its control (Log rank p=0.09). Pioglitazone, n=13; Control, n=15 for A-D. (* is P value <0.05).