Table 1.

Statistical Enrichment

A. PANTHER
Biological Process	Over/Under	P Value
5 to 12 months
Respiratory electron transport chain	+	4.3E-03
Oxidative phosphorylation	+	9.3E-03
Generation of precursor metabolites and energy	+	1.5E-02
12 to 24 months
Oxidative phosphorylation	−	2.0E-07
Respiratory electron transport chain	−	2.0E-07
Generation of precursor metabolites and energy	−	8.6E-05

B. DAVID
5 to 12 months	P Value
Gene Ontology Biological Process
Generation of precursor metabolites and energy	1.3E-47
Electron transport chain	1.6E-31
Oxidation reduction	3.5E-28
Cellular respiration	2.7E-21
Energy derivation by oxidation of organic compounds	5.6E-17
Gene Ontology Molecular Function
Cofactor binding	6.1E-15
Coenzyme binding	7.7E-15
Electron carrier activity	4.2E-9
Hydrogen ion transmembrane transporter activity	5.1E-9
Nucleotide binding	9.2E-9
12 to 24 months	P value
Gene Ontology Biological Process
Generation of precursor metabolites and energy	6.1E-61
Oxidation reduction	4.6E-38
Electron transport chain	1.1E-37
Cellular respiration	1.1E-15
Energy derivation by oxidation of organic compounds	1.1E-13
Gene Ontology Molecular Function
Cofactor binding	6.2E-15
Coenzyme binding	1.3E-14
Hydrogen ion transmembrane transporter activity	2.8E-13
Monovalent inorganic cation transmembrane transporter activity	6.5E-13
NADH dehydrogenase (ubiquinone) activity	2.3E-12