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. Author manuscript; available in PMC: 2016 Aug 1.
Published in final edited form as: Neuropharmacology. 2015 Apr 2;95:353–360. doi: 10.1016/j.neuropharm.2015.03.029

Figure 3. Contribution of GIRK channels to sex differences in layer 5/6 PrLC pyramidal neurons.

Figure 3

A) Summary of Ba2+-resistant baclofen-induced currents in layer 5/6 PrLC pyramidal neurons from adolescent male (M) and female (F) wild-type mice. Dotted rectangles show the average baclofen-induced currents measured in the absence of Ba2+ (from Fig. 1B). A significant interaction between treatment and sex was found (F1,39=8.4, P<0.001; n=8–11/group). Symbols: ***P<0.001 vs. male (within treatment). B) Summary of residual baclofen-induced currents in layer 5/6 PrLC pyramidal neurons from adolescent male (M) and female (F) Girk−/− mice, and comparison to currents measured in neurons from wild-type mice (dotted rectangles, from Fig. 1B). A significant interaction between genotype and sex was observed (F3,118=8.2, P<0.001; n=7–25/group). Symbols: *,*** P<0.05 & 0.001, respectively, vs. wild-type; #P<0.05 vs. male Girk3−/− mice. C) Representative baclofen-induced currents in layer 5/6 PrLC pyramidal neurons from adolescent male (left, black) and female (right, grey) Girk3−/− mice. D) Summary of rheobase data in layer 5/6 PrLC pyramidal neurons from adolescent male (M) and female (F) Girk3−/− mice. An interaction was found between sex and genotype (F1,81=7.1, P<0.01; n=18–24/group). Symbols: *P<0.05 vs. wild-type female.