Figure 2. Ablation of LXRs from NAV1.8 expressing neurons exacerbates high-fat diet induced thermogenesis.
(A) Body weight of LXRsNav mice and littermate controls on chow and Western Diet (WD) as followed over time (n = 12 per genotype) * for WD, # for normal chow (NC). (B) Adipose tissue as a percentage of total body weight in mice fed WD for 9 weeks, measured by NMR (n = 6). (C,D) Energy expenditure in weight-matched mice. (C) Calorimetry trace before and after a switch from NC to WD. (D) Energy expenditure during light and dark cycles before and after a switch from NC to WD. Error bars show S.E.M. *indicates p < 0.05.
Figure 2—figure supplement 1. Blood chemistry and lipid levels of LXRsNav mice.
Metabolite levels as measured by the UTSW metabolic core from LXRsNav and LXRsfl/fl mice fed 16 weeks with NC or WD. (A) Glucose. (B) Serum cholesterol. (C) Fatty acid (FFA). (D) Serum triglycerides. (E) Liver triglycerides. (F) Liver cholesterol.