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. 2015 Jan 31;6(8):6203–6217. doi: 10.18632/oncotarget.3357

Figure 1. Hepatotoxicity is highly accompanied with the anticancer activity of dasatinib.

Figure 1

Nude mice transplanted with A549 human xenografts were randomly divided into 2 groups (n=3 in each group) and treated with saline or dasatinib (50 mg/kg) for 30 days. A and B. The volume and RTV of xenograft tumors. C. The body weights of each group. (D-E) Nude mice were euthanized on day 30. D. Serum was analyzed for ALT, AST and LDH levels. E. Liver sections were stained with H&E (magnification=100× or 400×, scale bar=50 μm). Black arrows denote damaged hepatocytes. Data are expressed as the mean ± SEM. Statistical analysis was performed by t-test where appropriate. **P<0.01, ***, P<0.001 for significant differences compared to dasatinib-treated animals. DASA=dasatinib.