Skip to main content
. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Hypertension. 2015 May 11;66(1):199–210. doi: 10.1161/HYPERTENSIONAHA.115.05610

Figure 1.

Figure 1

Physiological characterization of Nppb+/+ and Nppb−/− rats. (A) Schematic organization of Nppb and ZFN generated targeted deletions in the M2 and M4 Nppb−/− (B) PCR amplification of Nppb gene in Nppb+/+, Nppb−/− M2, and Nppb−/− M4 strains, confirming 100 and 138bp deletions respectively. (C) Non-invasive blood pressure measurements; closed squares and open circles in Nppb+/+ (n=6) and Nppb−/− (n=16) respectively. (D) Invasive blood pressure measurements at three, six and nine months of Nppb+/+ and Nppb−/− rats. *, p<0.05; †, p<0.001, vs. Nppb+/+ rats.