Figure 1. Expression levels of miR-148a across four molecular subgroups of medulloblastoma, cell lines and miR-148a expressing stable polyclonal populations, as determined by real time RT-PCR assay.

(A) miR-148a levels were evaluated in 141 medulloblastoma tissues classified in the four molecular subgroups, normal developing (from less than 1year old infants) cerebellar tissues and adult (from individuals >21 yr of age) cerebellar tissues. (B, C, D) Relative Quantity of miR-148a in the indicated medulloblastoma cell line and its polyclonal populations transduced with pTRIPZ control lentiviral vector (Vector) or pTRIPZ-miR-148a construct expressing miR-148a in doxycycline inducible manner (P1, P2) and in the cells transiently transfected with control siGLO or miR-148a mimic. + DOX: doxycycline induced.