Table 1. Overview of the externally visible tumor phenotypes in animals injected at the 8-cell stage with 20 pg of apc TALEN mRNA in a single blastomere.
Animal-Dorsal | Animal-Ventral | Vegetal-Dorsal | Vegetal-Ventral | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
5 weeks | 9 weeks | 18 weeks | 5 weeks | 9 weeks | 18 weeks | 5 weeks | 8 weeks | 18 weeks | 5 weeks | 8 weeks | 18 weeks | |
n=14 | n=7 | n=4 | n=19 | n=10 | n=5 | n=18 | n=14 | n=7 | n=18 | n=7 | n=1 | |
Epidermoid cysts | 21% | 14% | 0% | 47% | 30% | 0% | 0% | 0% | 0% | 5% | 14% | 0% |
Desmoid tumors | 0% | 0% | 0% | 0% | 50% | 0% | 0% | 71% | 86% | 0% | 71% | 100% |
Limb tumors | 0% | 0% | 0% | 0% | 0% | 0% | 0% | 0% | 0% | 33% | 57% | 0% |
Survival (beyond 5 weeks) | 50% | 29% | 53% | 26% | 78% | 39% | 39% | 6% |