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. 2015 May 27;17(5):434–448. doi: 10.1016/j.neo.2015.04.004

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Effect of HSC-CAFs on tumor growth and vascularization. Measurement of size (A) and mass (B) of tumors showed that LLC + CAF co-injection (empty triangles) resulted in larger tumors versus LLC (empty circles) injected cohort (*P < .05). No tumor was observed in the CAF (black squares) cohort. (C) Extracted tumors from LLC and LLC + CAF cohorts; LLC + CAF cohort tumors show increased size and gross vascularity. (D) Immunofluorescence staining for anti-GFP (red) shows that the EGFP⁺ HSC-CAF population persists in the LLC + CAF cohort of tumors at endpoint (upper panels). No primary antibody staining is shown in the lower panels. Hoechst nuclear stain is represented in blue in merged images. (E) Immunohistochemical staining for CD31 with hematoxylin counterstain demonstrates increased vascularization (blood vessels indicated by asterisks) in the LLC + CAF cohort. (F) Quantification of blood vessels in LLC (white bar) and LLC + CAF (black bar) from immunohistochemical staining images (*P < .05). Bar, 25 μm (D).