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. Author manuscript; available in PMC: 2016 Dec 1.
Published in final edited form as: Biochimie. 2014 Dec 18;119:218–230. doi: 10.1016/j.biochi.2014.12.007

Fig 10. Frustration Serves a Functional Purpose.

Fig 10

A diagram showing the minimally frustrated web of interactions in two structural forms of – RhoA an allosteric protein. This web is indicated in green. The frustrated interactions in the regions shown in red lead to alternate nearly energetically degenerate configurations that allow these regions to function as hinges. The lower panel shows the frustration levels at different sequence locations, the red line indicating the number of frustrated contacts, green the number of minimally frustrated contacts. The black line indicates the local overlap of the two interconnecting structures. Notice the regions that move (and have low Q:) correspond to the most energetically frustrated regions. For details please see Ref 103.