Modified simultaneous integrated boost radiotherapy for large retroperitoneal malignant tumor: A case report

Abstract

The current study reports the case of a large retroperitoneal tumor treated with modified simultaneous integrated boost (SIB) radiotherapy. A 45-year-old female presented to the emergency department complaining of left abdominal pain and fever. A computed tomography scan detected a retroperitoneal tumor of 12×16×16 cm, and a biopsy revealed a poorly-differentiated adenocarcinoma. The patient was diagnosed with a large adenocarcinoma originating from the left ureter, with no distant metastasis. Due to the patient's poor physical condition, surgery was not recommended, and the patient was referred to the Department of Radiation Oncology (Yamagata University Hospital, Yamagata, Japan). Modified SIB radiotherapy was administered following the acquisition of written consent from the patient. The total irradiation dose to the center of the tumor and to the surrounding healthy tissue was ∼96 Gy/33 fractions and <60 Gy/33 fractions, respectively. At the end of the radiotherapeutic course, the tumor volume was reduced by ≥80%, and the residual tumor was surgically resected. As a result of the resection, a complete pathological response was confirmed; the patient has been recurrence-free for >3 years with no complications. Modified SIB radiotherapy may be safely administered, with favorable outcomes. Complete recovery can be achieved with this technique, even in a patient with a large radioresistant tumor.

Introduction

Retroperitoneal tumors arise from the tissues of the retroperitoneal space, which includes the following structures: The adrenal glands, kidneys, ureter, aorta, inferior vena cava, pancreas (part), duodenum, colon (part), rectum, esophagus, lymph nodes, and soft tissue. Although in other sites the incidence of a benign tumor is higher than that of a malignant tumor, the incidence of a malignant tumor in the peritoneum is ∼4 times higher than that of a benign tumor (1). The majority of retroperitoneal tumors are malignant soft tissue tumors, lymphoproliferative disorders, and malignancies arising from parenchymal tissues (1).

Approximately one-third of retroperitoneal tumors are soft tissue sarcomas, with liposarcoma and leiomyosarcoma accounting for ∼70% and 15% of reteroperitoneal sarcomas, respectively (2). The retroperitoneum is the second most common site of origin of soft tissue tumors (2), with 10–15% of soft tissue sarcomas arising from the retroperitoneum (3,4). More rarely, Castleman's tumors (5), adult neuroblastoma (6), gastrinoma (7), solitary fibrous tumor of the pancreas (8), teratoma (9) and neurogenic tumors (10) have been reported to occur in this region. Due to the rarity of retroperitoneal large adenocarcinoma, literature regarding the surgical treatment of large retroperitoneal tumors is limited (11). Furthermore, no standard treatment exists for patients with inoperable large retroperitoneal tumors and thus, only palliative chemotherapy or radiotherapy or best supportive care is administered for these patients.

Retroperitoneal tumors show few clinical symptoms in the early phase, and are typically detected incidentally by computed tomography (CT), or by palpation when they become larger. The current study reports the case of a patient with a large retroperitoneal tumor, which was treated with definitive radiotherapy and surgery. Written informed consent was obtained from the patient.

Case report

A 45-year-old female presented to the emergency department of Yamagata University Hospital (Yamagata, Japan) complaining of left abdominal pain and fever. The patient was initially diagnosed with left hydronephrosis caused by retroperitoneal abscess. Ureteral catheterization was performed to treat the left hydronephrosis, and antibiotics (intravenous meropenem, 1 g/day) were prescribed. However, the abdominal pain and fever had not improved after 2 weeks, and the patient was subsequently referred to the Department of Urology (Yamagata University Hospital).

A CT-guided core-needle biopsy of the retroperitoneal mass was performed. The mass, which was >10 cm in maximum diameter, and was determined to be a poorly-differentiated adenocarcinoma. An immunohistochemical examination revealed the following characteristics of the tumor: Cytokeratin (CK)7(+), CK20(-), CK5/6(-), carcinoembryonic antigen (CEA) (-), and carletinin(-). A CT scan showed a large tumor of 12×16×16 cm, with heterogeneous enhancement and irregular borders, located in the left retroperitoneum (Fig. 1). Left ureteral involvement of the tumor (Fig. 1A and C, black arrowheads) and secondary hydronephrosis were detected, however, there was no continuity between the tumor and the pancreas, adrenal glands, kidneys or stomach. The tumor was determined to be a poorly-differentiated adenocarcinoma arising from the left ureter (12). Although a small amount of ascites was observed in the abdomen, no definite peritoneal dissemination or distant metastasis was identified. The patient's plasma levels of carbohydrate antigen (CA)-125, CA19-9, and CEA were 201.3 U/ml (normal, <40 U/ml), 16.5 U/ml (normal, <37 U/ml), and 1.42 ng/ml (normal, <5 ng/ml), respectively; of these, only CA-125 levels were abnormally elevated.

Figure 1.

Computed tomography images prior to treatment. (A) Axial image showing the tumor of 12×16×16 cm located in the left abdomen (white arrowheads). The left ureter is involved in the tumor, and the ureteral catheter is visible in the tumor (black arrowhead). A small amount of ascites was also detected. (B) Coronal image showing the tumor with heterogeneous appearance and including cystic and solid components. (C) Sagittal image: Ureteral catheter penetrating the tumor (black arrowheads) and hydronephrosis were observed.

Definitive surgery was initially scheduled. However, due to the infiltration and rapid growth of the tumor, and the poor general condition of the patient, the possibility of surgery was excluded. The patient was referred to the Department of Radiation Oncology for palliation. She was unable to consume meals due to the large size of abdominal tumor, and her Eastern Cooperative Oncology Group performance status was determined to be 3 (13).

The initial radiation treatment consisted of coplanar, eight static field three-dimensional-conformal radiotherapy. The treatment was planned to irradiate the center of the tumor with 5 Gy/fraction, and the border area of the tumor and healthy tissue with <2 Gy/fraction (Fig. 2). In total, the center of the tumor was irradiated with 25 Gy/5 fractions and the border area of the tumor and healthy tissue was irradiated with 10 Gy/5 fractions. Subsequently, the center of the tumor was irradiated with an additional 20 Gy/4 fractions (Fig. 3A) and 26 Gy/10 fractions (Fig. 3B) using a modified simultaneous integrated boost (SIB) technique, and with 25.2 Gy/14 fractions using a standard technique (Fig. 3C). The cumulative dose to the center of the tumor and border area of the tumor was 96.2 Gy/33 fractions and 59.2 Gy/33 fractions, respectively (Fig. 3D). The equivalent dose in 2 Gy/fraction (EQD2Gy) was calculated using the following equation: EQD2Gy = (total dose) × (dose/fraction + α/β) / (2 + α/β) (14), and the α/β of the tumor was assumed to be 10 (15). The EQD2Gy of the center of the tumor was calculated to be ∼108 Gy, and the EQD2Gy of the surrounding healthy tissue was calculated to be ∼58 Gy. This radiotherapy with modified SIB technique was approved as a clinical trial by the Institutional Review Board of Yamagata University Hospital.

Figure 2.

The initial radiotherapy planning with modified SIB technique. The center part of the tumor was irradiated with a single dose of 5 Gy/fraction, while the dose to the peripheral region including healthy tissues was suppressed to <2 Gy/fraction. This treatment plan uses three-dimensional-conformal radiation therapy with eight static fields.

Figure 3.

(A) The second initial RTP with modified SIB technique. Field size was adjusted for tumor shrinkage. (B) The third RTP with modified SIB technique, consisting of one conformal arc and two static fields. (C) The fourth RTP with standard technique of three static fields. (D) Cumulative dose distribution of all RTPs (created image). The center part of the tumor was irradiated with >100 Gy in EQD2Gy, whereas the dose to the surrounding tissue was suppressed to <60 Gy in EQD2Gy. RTP, radiotherapy planning; SIB, simultaneous integrated boost; EQD2Gy, equivalent dose in 2 Gy/fraction.

Almost no side effects were caused by radiation therapy during the course of irradiation. Symptoms caused by the tumor decreased with the progression of the treatment, and the performance status at the completion of irradiation treatment was 0. The size of the tumor at the end of the irradiation was 7×6×15 cm (80% reduction in volume), and the cystic components and fibrotic septum without enhancing solid components were dominant in the tumor (Fig. 3C). After 47 days from the final day of irradiation, the patient underwent a combined resection of the tumor and adjacent organs (including part of the peritoneum and small bowel). Although no tumor regrowth was observed, the resection was performed for confirmation of tumor response as the patient's physical condition had improved and was considered suitable for surgery.

The resected tumor is shown in Fig. 4. Almost all of the cystic component was necrotic tissue, and xanthogranulomatous changes and fibrosis were observed in the peripheral region. No residual adenocarcinoma cells were observed (pathologically complete response). The ureter that was located in the center of the tumor was replaced by fibrotic tissue due to tumor invasion and irradiation, and pyelonephritis and hydronephrosis were observed in the left kidney. The patient has been recurrence-free for 3 years and 3 months, with no metastasis or complications.

Figure 4.

Macroscopic findings of the resected tumor. Cystic components included necrotic tissue, and the surrounding tissue was characterized by xanthogranulomatous changes or fibrosis. The left ureter was unclear due to degeneration and scarring. There was no malignancy.

Discussion

Soft tissue sarcoma or lymphoproliferative disorders are dominant in retroperitoneal neoplasms (1,3,4). Various types of adenocarcinoma of the retroperitoneum have been reported, including pancreatic cancer, renal cell carcinoma, mucinous adenocarcinoma (16,17), Müllerian adenocarcinoma (18), cystadenocarcinoma (19) and adenocarcinoma arising from retroperitoneal teratoma (20).

Surgical resection is typically used for the treatment of retroperitoneal malignant tumors, including soft tissue sarcoma, pancreatic cancer, adrenal cancer (3), whilst chemotherapy with/without radiotherapy is used for the treatment of lymphoproliferative disorders (21,22). Non-hematological tumors, including sarcoma, adenocarcinoma and neurogenic tumors, are usually insensitive to radiation. Furthermore, although microscopic lesions may be controlled with intraoperative or postoperative radiotherapy (23,24), radiotherapy is not used as the definitive treatment of retroperitoneal tumors. The tolerance dose of abdominal organs, such as the small intestine and duodenum, is ≤60 Gy in EQD2Gy; however, adenocarcinomas of >10 cm cannot be controlled with a total dose of 60 Gy, thus the required dose for control of large retroperitoneal tumors exceeds the tolerance dose of healthy tissues.

In the present case, modified SIB radiotherapy was used. The standard SIB technique can create contrasts in the dose distribution, and is used for head and neck or brain tumors (25,26). However, the dose distribution in the tumor is homogeneous in the standard SIB technique, and the dose received by the tumor usually does not exceed the tolerance dose of the surrounding healthy tissue. With the modified SIB technique, it is possible to irradiate the center of tumor with higher doses than the surrounding healthy tissue, by creating contrasts in the dose distribution in the tumor (27,28). This difference between the standard SIB technique and modified SIB technique is demonstrated in the present study. For example, as a single dose of 5 Gy is dangerous for the digestive tract, it is typically not used in abdominal radiotherapy. However, in the current patient, the modified SIB technique was used to safely irradiate the tumor with 5 Gy/fraction by reducing the dose to the surrounding tissue to <2 Gy/fraction (Fig. 2). The total irradiation dose received by the center of the tumor was calculated to be ∼108 Gy in EQD2Gy. Although this dose is not used in standard radiotherapy, the modified SIB technique allowed the safe administration of the scheduled radiotherapy. In addition, surgical resection was successfully performed without complications.

In conclusion, recent advanced technologies in radiotherapy have enabled the planning of precise and complex radiotherapy in the present case. The modified SIB technique is a new method that is considered to change the conventional concept that the irradiation dose must not exceed the tolerance dose of healthy tissues. This technique is particularly effective for large tumors in which a dose higher than the tolerance dose of healthy tissues is necessary. Furthermore, as demonstrated by the present case, complete recovery can be achieved for patients who cannot undergo surgery due to the advanced nature of the tumor. Modified SIB radiotherapy may be used in abdominal tumors and also in tumors arising at other sites (27). Future challenges include the establishment of a technique for the use of modified SIB radiotherapy and increasing the number of enrolled patients.