Table 4.

Principal components of the Chronic Migraine vs. Healthy Control classification model.

	DQDA	DT	Brain Hemisphere	MRI Features in PCs
Cortical Surface Area PCs
7		X	R	Caudal Anterior Cingulate
			R	Entorhinal
			R	Transverse Temporal
			L	Transverse Temporal
8		X	R	Entorhinal
			R	Rostral Anterior Cingulate
9	X		R	Transverse Temporal
			L	Temporal Pole
10	X		R	Caudal Anterior Cingulate
			R	Rostral Anterior Cingulate
			L	Entorhinal
			L	Transverse Temporal
11	X	X	R	Transverse Temporal
			R	Insula
			L	Parahippocampal
			L	Insula
15	X	X	R	Superior Temporal
			R	Temporal Pole
			L	Pars Triangularis
			L	Temporal Pole
17	X		R	Frontal Pole
			L	Superior Temporal
18	X		L	Entorhinal
			L	Supramarginal
Cortical Thickness PCs
21	X	X	R	Caudal Anterior Cingulate
			R	Isthmus Cingulate
			R	Posterior Cingulate
23		X	R	Isthmus Cingulate
			R	Parahippocampal
			R	Pars Orbitalis
			R	Rostral Anterior Cingulate
			R	Temporal Pole
			L	Parahippocampal
			L	Rostral Anterior Cingulate
27	X		R	Medial Orbital Frontal
			L	Entorhinal
			L	Isthmus Cingulate
28		X	R	Entorhinal
			R	Insula
			L	Superior Temporal
29	X		R	Pars Opercularis
			R	Pars Triangularis
			L	Caudal Middle Frontal
30	X		R	Superior Temporal
			R	Frontal Pole
			L	Entorhinal
			L	Parahippocampal
32	X	X	R	Pericalcarine
			L	Pars Triangularis
			L	Temporal Pole
Volume PCs
37		X	L	Caudal Middle Frontal
			L	Cuneus
			L	Lingual
			L	Paracentral
			L	Pericalcarine
38		X	R	Entorhinal
			R	Pericalcarine
			L	Cuneus
			L	Pericalcarine
			L	Temporal Pole
40		X	R	Entorhinal
			R	Parahippocampal
			R	Rostral Anterior Cingulate
			R	Transverse Temporal

The PCs that comprise the CM vs. Healthy Control classifiers derived via DQDA and DT are presented. The classifiers contained PCs consisting of cortical surface area, cortical thickness, and regional volume measurements. The left-most column contains the name of the PC. An “X” under “DQDA” or “DT” indicates that the PC was part of the classifier derived using DQDA or DT analyses in at least one of the ten iterations. The right-most column lists the brain regions for which structural measures comprise that PC, named according to FreeSurfer terminology. For example, PC₈ is comprised of cortical surface area measurements of the entorhinal cortex and rostral anterior cingulate. R = right; L = left.