Early visual deprivation has significant effects on choline, creatine and myo-Inositol and GABA concentrations in occipital but not precentral cortex. Absolute concentrations (in millimolar, mM) are shown across left and right occipital voxels and the precentral gyrus for A) choline, B) creatine, C) myo-Inositol, D) NAA. Group median metabolite concentrations are shown for sighted control (light gray bars) and early blind subjects (dark gray bars). Error bars represent the 25–75% interquartile range. * p < 0.05, ** p<0.01, *** p < 0.001 represent group differences using post-hoc Students t-tests corrected for 6 multiple comparisons using the Bonferroni-Holm method.