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. Author manuscript; available in PMC: 2016 Mar 12.
Published in final edited form as: Cell. 2015 Feb 26;160(6):1061–1071. doi: 10.1016/j.cell.2015.01.049

Figure 1. TREM2 deficient 5XFAD mice have increased hippocampal Aβ burden and accelerated loss of layer-V cortical neurons.

Figure 1

Aβ burden in 8.5 month-old Trem2−/−5XFAD, Trem2+/−5XFAD, and 5XFAD mice. (A) Matching coronal hippocampus and cortex sections were stained with an Aβ-specific antibody mHJ3.4. (B) Amounts of Aβ loads in hippocampi. (C–E) Soluble and insoluble Aβ1–40 and Aβ1–42 levels in hippocampi as detected by ELISA. (F–G) Densities of layer-V neurons in 8.5 month-old Trem2−/−5XFAD, Trem2+/−5XFAD and 5XFAD mice. (F) Matching coronal sections stained with cresyl violet. (G) Summary of densities of layer-V neurons. Original magnification: 10×; scale bar= 100µm. *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001, one-way ANOVA. Data represent analyses total of 8–10 5XFADmice, 8–12 Trem2+/− 5XFAD mice, and 8–16 Trem2−/−5XFAD mice (B, C–E, G). Bars represent mean±SEM. See also Figure S1.