Figure 2. Molecular dynamics simulation of mPEG-PLA-R8 micelle.
Each monomer consisted of a methoxy-poly(ethylene-glycol)(mPEG; MW ~ 2,000 g/mol; ) block coupled to the α-hydroxide of poly(lactide) (PLA; MW ~ 3,000 g/mol;
). As in the experiments, 28% of total monomers were modified with oligoarginine (R8;
) on the ω-carboxylate of the PLA block. The micelles were prepared with total 60 monomers.