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. 2015 Mar 10;6(10):8071–8088. doi: 10.18632/oncotarget.3513

Figure 9. BL-AD008 induces apoptosis in vivo.

Figure 9

(A) Immunohistochemistry of cleaved caspase-3 and -8, Bcl-2, Bax, ZIPK, p-AMPKα. IHC staining of the mouse orthotopic tumor tissues. IHC was used to determine the expression levels of apoptosis markers, which are cleaved caspase-3 and -8, Bcl-2 and Bax. And the ZIPK, p-AMPKα levels increasing (×200 magnification). Tumor tissues excised from the median dose group treated mice; *, P <0.05; **, P <0.01; ***, P<0.001. (b) Western blot analysis of AMPK, ZIPK, ERK1, cleaved caspase-3, -8 and -9. Tumor tissues excised from the HeLa xenograft mice were lysed.