Table 5.

Multiple Linear Regression: Significances.^a

Gene	r2	Sliding Speed (mm/s)	Time Point (hr)	Cycle No.b	Strain (%)	x-force (N)	z-force (N)	Modulus (MPa)	Maximum Stress (MPa)
Lubricin	0.73	0.011	0.012	0.005	0.479	0.029	0.425	0.029	0.031
MMP-3	0.52	0.610	0.097	0.546	0.337	0.158	0.834	0.799	0.732
MMP-13	0.45	0.905	0.163	0.866	0.287	0.221	0.651	0.919	0.841
ADAMTS-4	0.29	0.891	0.446	0.955	0.118	0.475	0.243	0.644	0.551
ADAMTS-5	0.73	0.772	0.021	0.618	0.047	0.018	0.835	0.789	0.976
TIMP-1	0.69	0.541	0.263	0.580	0.072	0.219	0.888	0.336	0.473
TIMP-3	0.89	0.033	0.146	0.050	0.060	0.054	0.025	0.001	0.002

^ar² values indicate the fit of the regression equation to explain the change in gene expression. The numbers below the mechanical parameters represent P values for each regression coefficient (Table 4).

^bCycle No. refers to the number of cycles during the 2-hour loading time.