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. 2015 Mar 14;6(13):11047–11060. doi: 10.18632/oncotarget.3567

Figure 1. DNA methylation/hydroxymethylation and expression of the Tet genes in Mdr2-KO liver at the late precancerous stage.

Figure 1

Total levels of 5mC (A) and 5hmC (B) in Mdr2-KO and in the age-matched Mdr2−/+ control liver determined by HPLC. (C, D) Expression of the Tet1 (C) and Tet2 (D) genes in the liver Mdr2-KO and Mdr2−/+ mice determined by real-time RT-PCR; RQ - relative quantification (normalized to Hprt values). Primers for the Tet genes described in [64]. Three 12-month-old males per group in all experiments; *, p < 0.05.