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. 2015 Mar 14;6(13):11047–11060. doi: 10.18632/oncotarget.3567

Figure 6. Direct correlation between expression and methylation of selected aberrantly methylated genes.

Figure 6

Hypermethylated genes Bmp8b, Cyba, Mmp23, Synpo were up-regulated, while hypomethylated gene Lrrc16a was down-regulated in the Mdr2-KO compared to the Mdr2−/+ liver at the late precancerous stage (three 12-month-old males per group). Semi-quantitative (for Cyba, Mmp23, Synpo and Lrrc16a) or real-time (for Bmp8b) RT-PCR normalized to Gapdh and quantified using the ScionImage software, *, p<0.05.