Skip to main content
. 2015 Mar 14;6(13):11074–11086. doi: 10.18632/oncotarget.3570

Figure 8. A proposed model depicting the mechanism by which Pygo2 represses E-cadherin expression and promotes metastasis of HCC cells.

Figure 8

Pygp2 repress E-cadherin expression not only via binding to E-cadherin promoter and promoting its promoter methylation directly, but also by up-regulating Zeb2 indirectly, and subsequently promoting HCC metastasis progress.