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. 2015 Feb 28;6(13):11295–11309. doi: 10.18632/oncotarget.3123

Figure 6. Effect of sFlk1 and Sunitinib on tumor growth and vascularization.

Figure 6

Tumors were generated by subcutaneous implant of B-CSC carrying an empty vector (Ctl) or a sFlk1 vector (sFLK1) (n = 8 per experimental group). Selected animals carrying Ctl tumors were treated daily with Sunitinib (SUN) from day 4. Panel A. Reduction of tumor volume and vascularization in sFLK1 and SUN tumors in respect to Ctl. Vessels quantification is the mean ± SD erythrocyte containing structures/field in at least 10 fields per tumor. Student's t test was performed: **= p < 0.001, *= p < 0.05 vs Ctl. Panel B. Representative micrographs of tumor sections stained with hematoxylin and eosin (upper panels) or with Masson's trichromic reaction (blu: connective, red: cells, yellow: erythrocytes; lower panels). The star indicated necrotic areas and the arrows vessels. Original magnification: H/H: 100x; Trichromic: 200x.