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. 2015 Mar 19;6(13):11447–11464. doi: 10.18632/oncotarget.3407

Figure 9. Blocking gap junction communication with a pharmacological inhibitor increases migration.

Figure 9

(A) Spheroid migration assay was carried out on control cells and cells that were treated with 150 μM of CBX, after 8 hours the cells were imaged and migration quantified (B) Inhibiting gap junction communication with CBX (150 μM) increases migration levels by 31%. The inactive analog GZA was unable to produce the same degree of increase in migration. This experiment has been repeated 3 times with n = 44 spheroids for each condition. *Student t-test was performed to calculate significance, *p < 0.05 was considered significance. Scale bar = 100 μm.