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. 2015 Mar 21;6(13):11547–11560. doi: 10.18632/oncotarget.3413

Figure 5. The effect of BCL6B on p53 signaling and apoptosis in HCC cells.

Figure 5

A&B. The expression of BCL6B, EGR1, MDM2, p53, p21, Bax, bcl-2, caspase-9, caspase-7, caspase-3 and PARP was detected by western blot in BCL6B unexpressed and re-expressed HepG2 and SNU449 cells. β-actin: internal control. C. IC50 value of 5-FU in BCL6B unexpressed and re-expressed HepG2 and SNU449 cells. The IC50 value of 5-FU was evaluated by CCK-8 activity. White columns: the IC50 value of 5-FU in BCL6B unexpressed HepG2 and SNU449 cells. Gray columns: the IC50 value of 5-FU in BCL6B re-expressed HepG2 and SNU449 cells.