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. 2015 Jul;100(7):914–926. doi: 10.3324/haematol.2014.113092

Figure 2.

Figure 2.

Effects of sub-lethal whole body irradiation on AML engraftment in NOD/SCID and NSG mice, and effects of engraftment on hematology. (A) Engraftment levels of AML-5 in the blood over time of irradiated and non-irradiated NOD/SCID mice and respective event-free survival curves. Each line represents the engraftment level of an individual mouse (B). Event-free survival curves of AML-4, AML-16, and AML-17 transplanted NSG mice with or without irradiation before transplantation. (C) Changes in hematologic parameters with AML-5 and AML-16 xenograft progression. Each individual point represents data from an independent mouse blood sample obtained at different time points; four to eight mice per experiment, results for AML-5 were from two independent experiments. The dashed lines represent respective hematologic parameters obtained from non-irradiated, non-engrafted control mice from four independent experiments with three to five mice per experiment.