Table 5. Selected list of markedly up-regulated genes during the observation period in the L-SWCNT and H-SWCNT group.
| Gene | L-SWCNT (DNA microarray) |
H-SWCNT (DNA microarray) |
H-SWCNT (qRT-PCR) |
||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| GenBank | name | 3 d | 7 d | 30 d | 90 d | 180 d | 365 d | 754 d | 3 d | 7 d | 30 d | 90 d | 180 d | 365 d | 754 d | 3 d | 7 d | 30 d | 90 d | 180 d | 365 d | 754 d | Description |
| NM_001011972 | Atp6v0d2 | 2.5 | 3.3 | 4.3 | 3.6 | 2.6 | 1.6 | 0.7 | 2.7 | 3.8 | 4.3 | 4.0 | 3.6 | 2.0 | 1.4 | 3.1 | 3.6 | 4.1 | 4.0 | 2.6 | 6.4 | 5.3 | ATPase, h+ transporting, lysosomal v0 subunit d2 |
| NM_031560 | Ctsk | −0.4 | 1.4 | 1.3 | 1.6 | 0.8 | 0.6 | 0.1 | −0.2 | 1.0 | 2.0 | 1.6 | 1.0 | 1.4 | 0.5 | −0.3 | 1.2 | 2.5 | 1.8 | 2.8 | 1.1 | 0.3 | Cathepsin k |
| NM_172091 | Gcgr | 0.2 | 0.6 | 1.8 | 1.8 | 1.5 | 1.7 | 1.1 | 0.5 | 1.2 | 1.9 | 2.6 | 2.7 | 1.8 | 1.8 | 0.1 | 3.3 | 2.0 | 2.6 | 2.5 | 4.1 | 0.9 | Glucagon receptor |
| NM_133298 | Gpnmb | 0.7 | 1.4 | 2.2 | 1.7 | 1.3 | 0.8 | 0.5 | 0.8 | 1.9 | 2.4 | 2.1 | 2.2 | 1.0 | 0.9 | 2.0 | 2.9 | 1.7 | 2.0 | 2.9 | 2.2 | 0.7 | Glycoprotein (transmembrane) nmb |
| NM_001013894 | Lilrb4 | 1.1 | 1.1 | 1.9 | 1.1 | 0.5 | 0.9 | 0.0 | 0.9 | 1.6 | 2.1 | 1.5 | 1.6 | 1.3 | 0.7 | 2.4 | 1.5 | 1.1 | 2.5 | 2.0 | 1.9 | 0.2 | Leukocyte immunoglobulin-like receptor, subfamily b, member 4 |
| NM_001105829 | Lpo | 2.8 | 3.9 | 6.0 | 6.0 | 3.8 | 0.8 | 0.0 | 3.0 | 4.6 | 6.0 | 6.9 | 5.7 | 2.5 | 1.2 | 3.7 | 6.5 | 7.0 | 7.8 | 6.7 | 2.8 | 4.4 | Lactoperoxidase |
| NM_001109011 | Marco | 0.8 | 2.6 | 2.6 | 3.8 | 0.2 | 0.4 | −0.6 | 1.2 | 2.6 | 2.5 | 4.9 | 1.0 | 1.7 | −0.2 | 3.4 | 5.4 | 5.9 | 6.3 | 3.3 | 2.4 | −0.4 | Macrophage receptor with collagenous structure |
| NM_012864 | Mmp7 | 2.4 | 4.3 | 4.4 | 4.1 | 2.4 | 3.5 | 2.4 | 3.1 | 5.2 | 4.9 | 4.6 | 3.5 | 4.2 | 2.8 | 3.2 | 5.2 | 3.6 | 3.3 | 4.0 | 7.1 | 5.0 | Matrix metallopeptidase 7 |
| NM_053963 | Mmp12 | 1.6 | 3.6 | 3.9 | 3.4 | 2.1 | 1.6 | 0.7 | 1.8 | 4.0 | 3.9 | 4.1 | 3.4 | 2.2 | 1.4 | 2.5 | 5.1 | 4.4 | 5.1 | 4.2 | 3.4 | 2.0 | Matrix metallopeptidase 12 |
| NM_001192002 | Mreg | 1.9 | 2.3 | 1.9 | 2.8 | 0.7 | 1.1 | 0.1 | 2.1 | 2.8 | 1.8 | 3.0 | 1.9 | 1.4 | 0.2 | 1.6 | 2.8 | 2.6 | 3.1 | 1.6 | 2.0 | −0.7 | Melanoregulin |
| NM_053968 | Mt3 | 0.1 | 0.6 | 0.9 | 1.5 | 3.0 | 3.1 | 1.8 | 0.4 | 0.8 | 1.1 | 2.1 | 4.0 | 3.1 | 2.5 | 0.4 | 0.3 | 0.6 | 5.1 | 5.3 | 5.4 | 1.5 | Metallothionein 3 |
| NM_019332 | Padi1 | 2.1 | 2.8 | 1.4 | 1.2 | 0.4 | 0.6 | 0.2 | 2.8 | 3.5 | 1.8 | 2.2 | 1.4 | 1.5 | 0.2 | 2.4 | 3.8 | 2.5 | 3.2 | 1.0 | 2.6 | −0.6 | Peptidyl arginine deiminase, type i |
| NM_001008561 | Rnase9 | 1.9 | 4.3 | 2.9 | 1.9 | 2.0 | 1.6 | 1.4 | 1.2 | 3.6 | 2.0 | 2.4 | 3.3 | 1.2 | 1.7 | 1.2 | 1.6 | 1.8 | 0.8 | 0.9 | 1.2 | 2.0 | Ribonuclease, RNAse a family, 9 |
| NM_019214 | Slc26a4 | 2.4 | 3.0 | 3.4 | 3.2 | 0.9 | 0.7 | −0.3 | 2.8 | 3.6 | 3.4 | 3.5 | 2.0 | 1.2 | 0.0 | 3.2 | 5.3 | 1.8 | 3.5 | 2.3 | 1.8 | −0.7 | Solute carrier family 26, member 4 |
| NM_012881 | Spp1 | 1.8 | 2.5 | 3.3 | 3.2 | 2.1 | 0.9 | 0.4 | 2.3 | 3.3 | 3.8 | 3.6 | 3.3 | 1.6 | 0.9 | 3.7 | 2.7 | 4.1 | 3.2 | 3.6 | 1.4 | 1.2 | Secreted phosphoprotein 1 |
| NM_053552 | Tnfsf4 | 2.5 | 3.3 | 0.7 | 1.6 | 0.1 | 1.1 | 0.4 | 2.3 | 4.0 | 0.7 | 1.1 | 0.4 | 1.4 | 0.8 | 2.1 | 3.2 | 1.0 | 2.1 | 0.4 | 0.6 | −0.4 | Tumor necrosis factor (ligand) superfamily, member 4 |
| NM_001106884 | Trem2 | 1.3 | 2.1 | 3.5 | 2.1 | 1.2 | 1.2 | −0.1 | 1.3 | 2.4 | 3.0 | 2.6 | 2.3 | 1.7 | 0.3 | 1.3 | 2.0 | 4.4 | 3.8 | 2.9 | 1.9 | 0.8 | Triggering receptor expressed on myeloid cells 2 |
Numerical values represent gene expression log-fold change compared to control levels. Log-fold changes with p values less or equal than 0.05 are shown in italics.