TABLE 1 ] .
Baseline Values
| Measure | All Subjects (N = 26) | LVRS (n = 9) | BLVR Responders (n = 7) | Control Subjects (n = 10) | P Valuea |
| Age, y | 60.6 ± 8.0 | 58.6 ± 9.2 | 60.1 ± 9.5 | 62.7 ± 5.8 | NS |
| BMI, kg/m2 | 24.7 ± 4.0 | 23.0 ± 4.5 | 27.7 ± 3.3 | 24.2 ± 2.8 | NS |
| Men | 96 | 89 | 100 | 100 | N/A |
| FEV1, L | 1.01 ± 0.31 | 1.07 ± 0.39 | 1.08 ± 0.29 | 0.90 ± 0.24 | NS |
| FEV1 % predicted | 37.8 ± 22.7 | 46.4 ± 33.4 | 40.5 ± 14.5 | 28.2 ± 10.7 | NS |
| FVC, L | 3.65 ± 0.90 | 3.57 ± 1.18 | 3.94 ± 0.51 | 3.52 ± 0.87 | NS |
| FVC % predicted | 102.0 ± 45.6 | 103.0 ± 47.9 | 118.2 ± 41.9 | 89.6 ± 30.1 | NS |
| FEV1/FVC | 0.28 ± 0.09 | 0.31 ± 0.14 | 0.27 ± 0.06 | 0.26 ± 0.03 | NS |
| RV % predicted | 217.8 ± 46.0 | 214.3 ± 43.1 | 198.1 ± 41.9 | 234.8 ± 49.2 | NS |
| TLC % predicted | 140.3 ± 22.7 | 140.5 ± 31.5 | 139.5 ± 23.7 | 140.7 ± 13.1 | NS |
| FRC % predicted | 184.4 ± 25.8 | 181.1 ± 32.6 | 174.9 ± 18.3 | 194.0 ± 22.3 | NS |
| Raw % predicted | 328.0 ± 135.2 | 291.5 ± 151.6 | 312.7 ± 155.4 | 371.5 ± 103.2 | NS |
| Tlcoc % predicted | 37.4 ± 10.9 | 33.1 ± 11.7 | 41.9 ± 12.2 | 38.1 ± 8.1 | NS |
| RV/TLC, % | 59.0 ± 7.6 | 58.1 ± 7.1 | 56.3 ± 5.87 | 61.6 ± 8.83 | NS |
| SGRQ, points | 61.2 ± 13.9 | 59.1 ± 12.1 | 62.7 ± 18.0 | 62.0 ± 13.5 | NS |
| mMRC dyspnea score, points | 2.67 ± 0.76 | 2.70 ± 0.70 | 2.67 ± 0.52 | 2.60 ± 0.97 | NS |
| 6MWD, m | 364.0 ± 79.2 | 390.6 ± 82.7 | 361.1 ± 63.8 | 342.4 ± 88.4 | NS |
| Tlim, s | 350 ± 189 | 340 ± 145 | 390 ± 130 | 326 ± 274 | NS |
| EELV isotime, L | 7.36 ± 1.33 | 7.08 ± 1.91 | 7.69 ± 0.66 | 7.61 ± 1.91 | NS |
| Pao2, kPa | 9.6 ± 1.2 | 10.0 ± 1.4 | 9.6 ± 1.1 | 9.3 ± 1.2 | NS |
| Paco2, kPa | 5.0 ± 0.8 | 5.0 ± 0.7 | 5.1 ± 1.1 | 4.8 ± 0.4 | NS |
Data are given as mean ± SD or %. 6MWD = 6-min walk distance; BLVR = bronchoscopic lung volume reduction; EELV = end-expiratory lung volume; FRC = functional residual capacity; LVRS = lung volume reduction surgery; mMRC = Modified Medical Research Council; N/A = not applicable; NS = not significant; Raw = airway resistance; RV = residual volume, SGRQ = St. George’s Respiratory Questionnaire; TLC = total lung capacity; Tlcoc = carbon monoxide transfer factor (corrected); Tlim = exercise time to limitation on cycle ergometer at 75% of the maximum achieved workload on a previous incremental peak exercise test.
a
Kruskal-Wallis test with Dunn multiple comparison test.