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. 2015 Apr 14;6(14):12080–12093. doi: 10.18632/oncotarget.3813

Figure 4. Evaluation of the effect of CDK5 activity on cell cycle protein expression in human MTC cells.

Figure 4

Immunoblots of lysates from MTC-SK cells transfected with either a control plasmid (Con) or a kinase-dead (Kd) CDK5 encoding plasmid for A) CDK2, CDK4 and CDK6; B) cyclin-A1,-B1,-E2 and C) p15INK4b, p16INK4a, p18INK4c, p19INK4d, p21CIP/WAF1 and p27KIP. P-values are p = 0.0244 for CDK2, p = 0.038 for CDK4, p = 0.009 for CDK6; p < 0.0001 for cyclin-A1, p = 0.0005 for cyclin-B1, p = 0.0116 for cyclin-E2; p = 0.0044 for p15INK4b, p = 0.4687 for p16INK4a, p = 0.1032 for p18INK4c, p = 0.0195 for p19INK4d, p = 0.0022 for p21CIP/WAF and p = 0.2674 for p27KIP1. Data are represented as mean +/− SEM, N = 4-6 for each condition.