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. 2015 Mar 12;6(11):8839–8850. doi: 10.18632/oncotarget.3559

Figure 2. Oncogenic EGFR CTED mutants are sensitive to EGFR inhibitors in vitro.

Figure 2

Growth of Ba/F3 cells transformed by CTED1 to CTED10 mutants was suppressed by either cetuximab (A), erlotinib (B), dacomitinib (C), or afatinib (D). Ba/F3 cells transformed by indicated CTED mutants were treated with the four EGFR inhibitors at the concentrations indicated for 72 hours and assayed for cell viability using Cell Counting Kit-8 reagents. Parental and Ba/F3 cells carrying the L858R mutant of EGFR were used as controls. The results are presented as a mean ±SD of sextuplicate wells and are representative of three independent experiments. Asterisk (*) indicates previously reported CTED mutants in GBM and lung adenocarcinoma.