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. 2015 Mar 20;6(11):9341–9354. doi: 10.18632/oncotarget.3322

Figure 5. sNEDD4 promotes tumor invasion through MMP9.

Figure 5

(A) MMPs protein levels and activities were determined using Western blot (upper) and gelatin zymography (lower) analyses. (B) Invasion abilities of sN1 cells infected with LacZ shRNA (shLacZ) or MMP9 shRNA (shMMP9) were determined with the Transwell invasion assay, and the corresponding MMP9 activities shown in panel (C) Western blot (D) and gelatin zymography (E) were performed with proteins extracted from primary tumors of orthotopic mouse model.