Table 1. Correlation of CIP4 expression with clinicopathological and molecular features of human invasive ductal carcinomas.

Feature	Total (n = 245)	CIP4 IHC staining				p-valueb
		CIP4 lowa		CIP4 higha
		(n = 201)	%	(n = 44)	%
Age						0.315
range 24 – 50	95	75	79	20	21
range 51 – 92	150	126	84	24	16
age (mean ± s.d.)		56 ± 0.89		54.8 ± 1.77
Menopausal status						0.821
Pre	91	74	81	17	19
Post	154	127	82	27	18
Tumor Size (cm)						0.118
≤ 2	30	27	90	3	10
> 2 and ≤ 5	139	117	84	22	16
> 5	76	57	75	19	25
Tumor Grade						0.301
1	37	33	89	4	11
2	141	117	83	24	17
3	66	51	77	15	23
n.d.c	1
Tumor Stage						0.041
1 + 2	145	125	86	20	14
3 + 4	100	76	76	24	24
Lymph node status						0.508
Negative	86	73	85	13	15
Positive	157	128	82	29	18
ER						< 0.001
Negative	71	47	66	24	34
Positive	174	154	89	20	11
PR						< 0.001
Negative	114	82	72	32		28
Positive	131	119	91	12		9
HER2						0.025
Negative	210	177	84	33		16
Positive	35	24	69	11		31
Perou/Sorlie classification						< 0.001
Luminal	182	162	89	20	11
HER2	22	13	59	9	41
Basal-Like	41	26	63	15	37

^aCIP4 low: Positivity < 0.87, CIP4 high: Positivity ≥ 0.87; Percentages of samples for each variable are shown in parentheses; values in bold indicate statistically significant correlations (p < 0.05); s.d. means standard deviation;

^bp values to evaluate the dependency between each variable and CIP4 staining were calculated using a Chi-square test;

^cn.d. means no data