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. 2015 Apr 23;6(12):9657–9668. doi: 10.18632/oncotarget.3922

Table 3. List of DUBs discussed in this review that rely on binding to WD40 proteins.

DUB WD40 Cellular processes
Usp1 WDR48 (Uaf-1) DNA damage response, Fanconi anaemia pathway, homologous recombination, cellular differentiation and Akt signalling
Usp3 WDTC1 DNA repair and cell cycle progression
Usp7 BUB3, WDR21A, RAE1 Gene expression, protein stability, cell cycle progression and proliferation
Usp12 WDR20, WDR26, WDR48, WDR77, DMWD Transcription, Notch signalling and Akt signalling
Usp22 TAF5L Gene expression, protein stability, proliferation and cell cycle progression
Usp42 WDR18 Transcription, stress response and cell-cycle progression. When fused to RUNX1 it is involved in pathogenesis of acute leukaemia
Usp44 TBL2 DNA repair, cell cycle progression and differentiation
Usp46 WDR20, WDR26, WDR48, WDR77, DMWD Transcription, nervous system development and Akt signalling
Usp49 COPA Gene expression and pre-mRNA processing
Usp50 PRPF4 Cell cycle progression