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. 2004 Jul 10;329(7457):111. doi: 10.1136/bmj.329.7457.111-a

Raised cardiac troponins

Troponin is raised in pre-eclampsia

Adam Morton 1
PMCID: PMC449874  PMID: 15242925

Editor—In their editorial on raised cardiac troponins Ammann et al omit an important cause of increased troponin concentration in obstetric medicine—gestational hypertension and pre-eclampsia.1

Fleming et al showed fivefold higher median values for cardiac troponin I in preeclamptic women than in normotensive pregnant women.2 These median values were above those which would be indicative of significant myocardial damage. Awareness of this becomes important in women with severe pre-eclampsia complicated by pulmonary oedema, the pathogenesis of which is likely to be multifactorial related to capillary leak, hypoalbuminaemia, hypertension, and global left ventricular dysfunction. It is also important as the other commonly used marker of myocardial ischaemia, the MB isoenzyme of creatine kinase, is raised in around a third of normal pregnant women on the first postpartum day after vaginal delivery.3

Competing interests: None declared.

References

  • 1.Ammann P, Pfisterer M, Fehr T, Rickli H. Raised cardiac troponins. BMJ 2004;328: 1028-9. (1 May.) [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 2.Fleming SM, O'Gorman T, Finn J, Grimes H, Daly K, Morrison JJ. Cardiac troponin I in pre-eclampsia and gestational hypertension. Br J Obstet Gynaecol 2000;107: 1417-20. [DOI] [PubMed] [Google Scholar]
  • 3.Leiserowitz GS, Evans AT, Samuels SJ, Omand K, Kost GJ. Creatine kinase and its MB isoenzyme in the third trimester and the peripartum period. J Reprod Med 1992;37: 910-6. [PubMed] [Google Scholar]

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