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. 1994 Oct 11;91(21):10222–10226. doi: 10.1073/pnas.91.21.10222

Cell interactions in the control of size in Drosophila wings.

A García-Bellido 1, F Cortés 1, M Milán 1
PMCID: PMC44990  PMID: 7937866

Abstract

The vein locus (vn) includes lethal alleles (designated also defective dorsal discs) that prevent growth of dorsal discs and in viable genetic combinations reduce the number of cells of the adult wing. Those effects are prominent in genetic mosaics. Cell proliferation is reduced in all regions of the wing blade in a local autonomous way. These effects are more extreme when mutant clones occupy full intervein regions bordering veins. Clones have, in addition, nonautonomous effects (accommodation) in the proliferation of wild-type cells of the same wing. These effects are more extreme in double mutant vn (ddd) and ve (rhomboid) allelic combinations. Developmental analysis shows that cell proliferation stops earlier in larval development the stronger the vn allele considered. A model is discussed of how cell proliferation is controlled by cellular interactions.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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